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Surfactant aggregation in magnetic ionic liquids
This proposal aims to explore aggregation behavior of common surfactants in magnetic ionic liquids (MILs) and to investigate the effect of a magnetic field on aggregate size,... -
Investigation of zwitterionic surfactant templated bio-polymer films as senso...
We have found it possible to deposit mesostructured surfactant templated polymer thin films on solid substrates. To date the majority of work has used hexadecyltrimethylammonium... -
RESUBMISSION : DNA hybridisation-mediated vesicle fusion - kinetics and fate ...
Controlled vesicle fusion has major advantages in diagnostic and drug delivery applications. We have designed a DNA hybridisation-based assay for directed fusion of vesicles... -
PROBING DRUG PHARMACODYNAMICS BY QENS: THE EFFECT OF CISPLATIN-LIKE ANTICANCE...
This dataset has no description
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Structure-function studies of Replication Protein A, a crucial player in geno...
Replication protein A (RPA), the eukaryotic ssDNA binding protein, is a heterotrimeric protein required for almost all aspects of cellular DNA metabolism. RPA binds... -
Kinetic Study of the Mechanistic Complexation Process Between DNA and Cationi...
We propose to use the new SANS2d to study the dynamic structural evolution in the couse of the formation of DNA-cationic polymer complexes. The dynamic process and the mixing... -
Investigation of zwitterionic surfactant, Ca2+ and bio-polymer interactions
We are currently investigating the formation and structure of surfactant-templated polymer films comprised of cat-anionic surfactant mixtures and a variety of polymers. As we... -
Structure of siRNA containing delivery vehicles: effect of serum
Complexes prepared from cationic, dichain lipid (L) vesicles and negatively charged siRNA (R), with and without positively chargely targeting peptides (P) known as LR or LPR... -
Molecular interactions between phospholipid monolayers and dimethylsulphoxide
Neutron reflectivity will be employed to investigate the interaction between dimethylsulphoxide and monomolecular films of phosphatidylcholine. The monolayer will be used as a... -
Conformational changes on interaction of cytochrome c with lipid monolayers.
The main objective of the present work is to gain an understanding of the interaction of the cationic protein, cyt c with anionic lipid membranes. This objective will be... -
Interaction of the nucleic acid, DNA, with a model biomembranes of varying ri...
In this experiment we aim to investigate, using neutron reflectometry in combination with contrast variation, the intermolecular interaction between the nucleic acid, calf... -
PROBING THE NEAR AND INTERMEDIATE RANGE NANOSTRUCTURE OF DNA/PEPTIDE HYDROGELS
The near- and intermediate-range order within peptide and peptide/DNA hydrogels will be probed across the q range available on NIMROD. Samples will be prepared in H2O/D2O... -
Anisotropic Displacement Parameters and Diffuse Scattering in Graphite
The accurate description of van-der-Waals forces within DFT is currently one of the most active areas of research in computational physics and chemistry. In the case of soft... -
SANS contrast measurements on important protein/DNA interactions from RCaH
This proposal is to perform SANS contrast measurements on three protein/DNA interactions currently worked on at the Research Complex at Harwell. This is part of an ongoing... -
Structure-function studies of Replication Protein A and its complexes with DNA.
Replication protein A (RPA), the eukaryotic ssDNA binding protein, is a heterotrimeric protein required for almost all aspects of cellular DNA metabolism. RPA binds... -
DNA unwinding mechanism of the archaeal helicase PabMCM in its octameric conf...
The process of cell division requires precise duplication of the genetic material. The separation of the two strands of DNA and the progression of the replisome are driven by... -
Binding of DNA to Model Membranes in the Presence of Ca2+ Ions and a Membrane...
The aim of the present work is to gain an understanding of the interaction of DNA with the phospholipid bilayers. The effect of different forms of DNA, the presence of divalent... -
PROBING DRUG PHARMACODYNAMICS BY QENS: THE EFFECT OF CISPLATIN-LIKE ANTICANCE...
Water supports vital biochemical processes in living organisms, namely through maintenance of the three-dimensional architecture of biopolymers by a tight interplay with their... -
Surface structure of monolayers formed by novel di- and tri-chain cationic li...
The aim of the present study is to the determine, using specular neutron reflection (SNR), the structure of layers formed by novel tri-chain cationic lipids in combination with... -
Measurement of the hydration of B-DNA
Water is intimately entwined structurally with DNA. Depending on its hydration state, DNA can form several forms: A, B, C, D and Z. In addition water bound in the grooves of the...
