Water supports vital biochemical processes in living organisms, namely through maintenance of the three-dimensional architecture of biopolymers by a tight interplay with their hydration shells. Hence, any mobility changes within this hydration layer may affect the biopolymer´s conformational and dynamical profile, which rule biofunctionality.Building on the success of a previous experiment on human cells (RB1510054, paper under review [1,2]), the present study aims to apply QENS (with isotope labelling) for probing the effect of cisplatin-like anticancer drugs on the dynamical behaviour of DNA, through the impact on its hydration layer. This is a timely and innovative way of tackling a drug´s pharmacodynamics at a molecular level, that should provide data allowing a thorough understanding of the drug´s mode of action, water being suggested as a secondary pharmacological target.