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Structural studies of thermal responsive nanogels at the oil-water interface
It has been shown that gel particles are able to stabilize the oil-water interface and forming emulsions ( the so called "Pickering emulsions"). It has also been shown that... -
The interaction of cytochrome c with floating bilayers containing negatively ...
As research on apoptosis has gained momentum, the importance of membrane lipids in this crucial cellular process is becoming clear.Previously, we have determined using NR and... -
7D_TRANS
This dataset has no description
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Aggregation behaviour of PEGylated ibuprofen
In the present study the acidic, anti-inflammatory drug, ibuprofen has been PEGylated using an polyoxyethylene chain of 750 molecular weight. The consequence of this PEGylation... -
Determination of the absorbed amount and location of a hydrophobic drug in su...
Many drugs are both poorly water-soluble (hydrophobic) and lipophilic in nature and are therefore incorporated into surfactant micelles and monolayers. As the incorporation of... -
Structure of oil-in-water microemulsions containing eutectic mixtures of ment...
Although microemulsions have been widely investigated as potential drug delivery vehicles, relatively little work has been performed establishing the detailed molecular... -
Investigation of phosphatidylcholine and its interaction with 1,2 propandiol ...
The aim of the present study is to use neutron diffraction enhanced with isotopic substitution and subsequent computer simulations to determine the head group solvation of a... -
V plate 3mm SC Pos 0 25C Jaws 30x30mm2 Beam Scraper 30mm diameter
This dataset has no description
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Detailed Structure of Phospholipid Bilayers from Multiple Contrast Neutron Re...
In recent monolayer measurements, we have developed models for obtaining detailed structural information of phospholipid structures. The models employ a 'quasimolecular'... -
Surface structure of monolayers formed by novel di- and tri-chain cationic li...
The aim of the present study is to the determine, using specular neutron reflection (SNR), the structure of layers formed by novel tri-chain cationic lipids in combination with... -
Interactions of lipidic cubic nanoparticles with model lipid biomembranes at ...
Lipidic cubic nanoparticles (LCNPs) have been extensively studied as therapeutic agents and delivery systems due to their biocompatibility, ease of drug encapsulation and... -
Determination of the absorbed amount and location of a hydrophobic drug in su...
Many drugs are both poorly water-soluble (hydrophobic) and lipophilic in nature and are therefore incorporated into surfactant micelles and monolayers. As the incorporation of... -
Location of the lipophilic drug, testosterone propionate in surfactant monola...
Many drug molecules are both poorly soluble in water and lipophilic or slightly amphiphilic innature and, as a consequence, are incorporated into surfactant micelles and into... -
Microemulsion formulations for local anaesthesia
Although microemulsions have been investigated as potential drug delivery vehicles, little work has been performed establishing the detailed molecular architecture of the... -
Binding of DNA to Model Membranes in the Presence of Ca2+ Ions and a Membrane...
The aim of the present work is to gain an understanding of the interaction of DNA with the phospholipid bilayers. The effect of different forms of DNA, the presence of divalent... -
The structure of ceramides in a model membrane environment
This proposal aims to investigate the structure of ceramide, an important component of cellular membranes in a mimic membrane environment. After assessment of this molecule in... -
Neutron reflectivity studies of the interaction of amphotericin with phosphol...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin (AmB) has created a demand for novel anti-fungal agents that can circumvent the pathogens¿... -
Solubilisation in Zwitterionic Micelles: Effect of Structure
The project aims to probe the relationship between surfactant structure, the micelles formed in solution, and the type of drug molecules that the micelles solubilise. Once... -
Solvation dynamics of the phosopholipid 1,2-dipropanoyl-sn-glycero-3-phosphoc...
It is well known that water is the medium in which the overwhelming majority of biological processes take place. In cell membranes water molecules are thought to be essential to... -
The mode of action of a novel disruptive antimicrobial technology on model me...
A Unilever proprietary technology has been shown to inhibit biofilm growth and development, and is also found to possess antimicrobial activity, effective both as a...
