The mode of action of a novel disruptive antimicrobial technology on model membranes.

DOI

A Unilever proprietary technology has been shown to inhibit biofilm growth and development, and is also found to possess antimicrobial activity, effective both as a broad-spectrum antibacterial and as an antifungal agent. This is unusual and requires both specific and holistic understanding of the agent’s mode of action at a molecular level. In the studies proposed here (performed using the technique of small angle neutron scattering), we aim to determine the effect of this potential new drug on model fungal, bacterial and mammalian cell membranes. We hope then to elucidate the key common factors which render the technology effective in controlling biofilm formation as well as exploring the its impact on different infective organisms.

Identifier
DOI https://doi.org/10.5286/ISIS.E.98004714
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/98004714
Provenance
Creator Mr Xing Chen; Dr Delaram Ahmadi; Professor Jayne Lawrence; Dr Najet Mahmoudi; Dr Farooq Malik; Dr Dave Barlow; Dr Fabrizia Foglia; Dr Ian Tucker
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2018-10-21T08:00:00Z
Temporal Coverage End 2018-10-23T08:00:00Z