Microemulsion formulations for local anaesthesia

DOI

Although microemulsions have been investigated as potential drug delivery vehicles, little work has been performed establishing the detailed molecular architecture of the drug-containing microemulsions. The present study uses the novel approach of using a eutectic mixture of two local anaesthetics namely menthol and lidocaine, as the free base, as the ¿oil¿ to prepare a pharmaceutically acceptable microemulsion suitable for anesthesia of the mouth or the skin. Small angle neutron scattering measurements in combination with contrast variation will be used to determine the location of the eutectic mixture in the microemulsion as a function of composition and surfactant (either dodecyldimethylammoniopropane-sulfonate, sodium dodecyl sulphate or dodecyl trimethyl ammonium bromide). The study is part of on-going project in our group investigating microemulsions as drug delivery vehicles.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24090605
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24090605
Provenance
Creator Professor Jayne Lawrence; Professor Gino Martini; Ms Yuvared Luangwitchajaroen; Dr Hisham Al-Obaidi; Mr Yussif Saaka
Publisher ISIS Neutron and Muon Source
Publication Year 2016
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2013-06-07T07:49:50Z
Temporal Coverage End 2013-06-10T08:25:53Z