Investigation of phosphatidylcholine and its interaction with 1,2 propandiol and water

DOI

The aim of the present study is to use neutron diffraction enhanced with isotopic substitution and subsequent computer simulations to determine the head group solvation of a very short dichain chain phosphatidylcholine molecule in a 30 mol% mixture of 1,2 propandiol and water in order to understand why the presence of 1,2 propandiol in a formulation leads to greater drug penetration into the skin. It is of particular interest in the present study to determine whether the 1,2 propandiol preferentially solvates the lipid head group as has been suggested by some researchers. A mixture of 30% of 1,2 propandiol in water was selected for this study as it has been shown that this system leads to an enhanced skin penetration of a range of poorly-water soluble drugs.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24089212
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24089212
Provenance
Creator Professor Jayne Lawrence; Dr Richard Harvey; Dr Sylvia McLain; Dr Silvia Imberti; Miss Louise Collins; Dr Fred Campbell
Publisher ISIS Neutron and Muon Source
Publication Year 2015
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2012-07-19T08:30:06Z
Temporal Coverage End 2012-10-08T08:39:45Z