41 datasets found

Perfluoroalkyl substances (PFASs) are stable compounds and commercially desirable. They are widely used, for example, as surfactants in textile and paper products and in aqueous...

Due to increasing antibiotic resistance, bacteria membrane disrupting antimicrobial peptides (AMPs) are of increasing interest as alternatives to classical antibiotics. AMPs are...

The aim of the present work is to gain an understanding of the interaction of DNA with the phospholipid bilayers. The effect of different forms of DNA, the presence of divalent...

We have been investigating the influcence of the cationic staphylococcal lipid lysyl-phosphatidylglycerol (L-PG) on bacterial resistance to antimicrobial peptides (AMPs). Using...

The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the...

Recently (RB19100102) we have discovered that floating bilayers composed of fluid phase lipids can be produced by deposited vesicles onto charge modified oligo(ethylene...

The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the...

In recent years we have had considerable success with the surface modification of amorphous and crystalline thermal plastic polymers using multi-end functional additives. In...

The anti-fungal agent amphotericin B (AmB) can be administered to patients in aqueous solution complexed with cholesteryl sulfate (CS), and this formulation helps to minimise...

Complexes prepared from cationic, dichain lipid (L) vesicles and negatively charged siRNA (R), with and without positively chargely targeting peptides (P) known as LR or LPR...

Our objective is to create asymmetric solid surface tethered bilayers (tBLMs) with the the outer leaflet predominately populated by charged phospholipids. tBLMs are produced by...

This proposal is part of a broad programme of collaborative research between RAL / Oxford and Unilever, using predominantly scattering techniques to investigate the nature of...

Gram negative (-ve) bacteria possess numerous defenses against antibiotics, not the least of them being the intrinsic permeability barrier afforded by their outer membrane (OM)...

Asymmetry across biological membranes is vital for a wide range of organelle and cellular functions. Significant differences in lipid composition have been found between the...

The key to the use of polymer vesicles as effective molecular delivery systems is in the ability to efficiently encapsulate a molecular payload within the vesicle. We would like...

'Floating LSupported Bilayers' (FSB's) have become the 'standard' systems used for studying membrane systems using reflectivity at ISIS and other facilities. They are reliable,...

The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the...

Membrane receptor proteins (MRPs) which are thought to represent the majority of drug targets are challenging to study as their structure and function is dependent on being...

For polymer vesicles to act as effective molecular delivery systems we must efficiently encapsulate a molecular payload within the vesicle. We would like to use neutron...

The cell membrane is a very important structure in biology and many laboratory based model systems have been developed to study it using biophysical techniques. Our particular...