Bilayer lipid membranes and their interactions with the integral or peripheral proteins serve as one of the key mechanism in various cellular functions like communication, cell defences, signal transduction etc. In the cell membranes the lipid bilayers acts as filter or switchable gate way, controlling the flow of nutrients into and metabolic wastes out of the cells and organelles. The sensitivity of these lipid molecules in the membranes to local concentration of ions changes dramatically the surface tension, stretching and bending elasticity, viscosity of the membrane and is believed to have key role in cell membrane fluidity or permeability. In this proposal, we will investigate the interaction of flexible or semi-flexible long chain proteins with the lipid monolayer which can help to predict the transport of molecules through cell membrane and the flexibility in shape/size of cells.