Neutron reflectivity studies of the interaction of Amphotericin B with biomimetic lipid monolayers

DOI

Bio-surfactants that can be harvested from micro-organisms are of particular interest, because these can potentially be harvested in high yield and at low cost. In this category of bio-surfactants, are the rhamnolipids that are produced by various forms of bacteria. Rhamnolipids not only show very low-toxicity and are bio-degradable, they can now be produced with high efficiency allowing for economical production and industrial scalability. These characteristics, together with their proven anti-fungal activity, makes them very promising candidates for use in manufacture of active drug delivery systems for drugs like amphotericin B. In the studies proposed here, we aim to carry out neutron reflectivity experiments to determine the structure of the AmB-containing monolayers formed at the air-water interface by rhamnolipid(/sterol) with and without AmB.

Identifier
DOI https://doi.org/10.5286/ISIS.E.98004140
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/98004140
Provenance
Creator Dr Mario Campana; Dr Fabrizia Foglia; Dr Dave Barlow; Dr Farooq Malik; Dr Delaram Ahmadi
Publisher ISIS Neutron and Muon Source
Publication Year 2021
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2018-10-05T08:00:00Z
Temporal Coverage End 2018-10-10T09:43:19Z