Bacterial lipoteichoic-acid (LTA) micelles: From molecular self-assembly to mediating septic shocks

DOI

Whilst the biological effect of lipoteichoic-acid (LTA) contributing to bacterial infections is widely reported in microbiological and immunological studies, very little is understood on a physicochemical level; for instance, the amphiphilic nature of LTA would drive its self-assembly into different aggregates such as micelles and liposomes, which would be directly relevant to how it mediates interactions with biological surfaces, biofilm formation, and consequent septic shocks. We propose a first SANS study of the self-assembled structure (size, shape, and aggregation number) of LTA micelles (with a reported critical micelle concentration ~ 2-5 µg ml-1) extracted from Bacillus Subtilis at different concentrations (2-1000 µg ml-1) and temperatures (25-45 oC), as well as different ionic strengths using mono-/di-/tri-valent cations.

Identifier
DOI https://doi.org/10.5286/ISIS.E.RB1920280-1
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/105603055
Provenance
Creator Dr Sarah Rogers; Miss Holly Stockdale; Miss Lauren Matthews; Professor Wuge Briscoe; Dr Bhaveshkumar Narendrabhai Bharatiya; Mr Gang Wang; Miss Charlotte Kenton
Publisher ISIS Neutron and Muon Source
Publication Year 2022
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2019-10-13T08:00:00Z
Temporal Coverage End 2019-10-15T14:46:06Z