Individuals of Corbicula largillierti were manually collected between 0 and 1 m depth from "Los Chorrillos" stream, at the upper part Suquía River Basin (Córdoba, Argentina 31.399849° S; 64.509624° W) during December 2017. The amount of oxygen consumed per unit of time (vO2) plotted as a function of the environmental oxygen levels (pO2) is one of the typical approaches to study measuring hypoxia tolerance of aquatic invertebrates to their environment. In this case, the vO2 (mg O2/g dm/h) of 18 individuals of Corbicula largillierti under decreasing pO2 (mg O2/l ) measured at 25ºC. Morphometric parameters (shell length (mm), shell height (mm)and dry mass without shell (g)) of each individual is included.