28 datasets found

This proposal is to perform further SANS contrast measurements on three protein/DNA interactions currently worked on at the Research Complex at Harwell. This is part of an...

A very important property of O/W microemulsions is the exchange dynamics of the oil molecules. So far little is know about that, despite the fact that its control is crucial for...

Gastric mucus is a vital component for the protection of the stomach from the highly acidic gastric secretions, preventing autodigestion and providing mechanical protection....

Measurements are required for Sans2d resolution checks and also the overlap of the two Sans2d detectors. Proposal submitted to panel and they deemed it should be done as...

Gram negative bacteria cause a wide range of diseases. Colicins are protein toxins capable of penetrating the outer membrane barrier and killing the bacteria. Thus they...

Abnormally glycosylated IgA leads to IgA nephropathy, the most common cause of renal failure. IgG antibody represents one-third of new drugs currently in development, and its...

Replication protein A (RPA), the eukaryotic ssDNA binding protein, is a heterotrimeric protein required for almost all aspects of cellular DNA metabolism. RPA binds...

Gram negative bacteria cause a wide range of diseases including meningitis, bubonic plague, gonorrhoea, diarrhoea, Legionnaires' disease and cholera. Their outer membrane...

IgG antibody represents one-third of new drugs currently in development. We will unravel the solution structures of the Fab and Fc fragments within IgG. Following our earlier...

We propose SANS measurements of 4He in a region of supefluid transition (2.2 K). The main aim of the experiment is to see whether at small-angle scattering there is an...

Endocytosis plays a central role in allowing the selective transport of molecules, via membrane-derived vesicles, into cells. Vesicle formation is controlled by a complex...

Replication protein A (RPA), the eukaryotic ssDNA binding protein, is a heterotrimeric protein required for almost all aspects of cellular DNA metabolism. RPA binds...

Endocytosis plays a central role in allowing the selective transport of molecules, via membrane-derived vesicles, into cells. Vesicle formation is controlled by a complex...

The proposed research project is targeted to the investigation of the characteristics of eumelanin, a heterogeneous material insoluble in water and in any organic solvent, as...

This proposal aims use a novel approach whereby deuterated amyloid peptide fibrils are givenhydrogenated growing ends, and analysed using SANS. The data will enable us to...

Polyurethane foams (PUFs) are commonly prepared by mixing Pluronic type copolymers and isocyanate reactive monomers in the presence of additives e.g. catalysts, blowing agent...

When cells are subjected to stress, such as drying, globular proteins are observed to unfold and irreversibly aggregate. Certain intrinsically disordered proteins (IDPs) do not...

Hydrophobins are secreted fungal proteins and are small lipopeptide biosurfactants. They are strongly surface active and self-assemble at interface, and these unique film...

Large multiprotein complexes are the new frontier in structural biology. Individual proteins may be solved by X-ray crystallography but the relationships between subunits and...

Recent experiments on SANS2D have indicated that small colloidal particles can act as macroions that screen the charged interactions of larger particles. This can cause changes...