Modes of protein adsorption at polyethylene oxide brushes of various polymer coverage

DOI

We wish to understand the mechanism to which polymer brushes such as PEO resist the adsorption of protein and thus offer biocompatibility for various surface applications. Preliminary experiments and recent theory suggest that the protein adsorption is a random sequential process proportional to polymer coverage. To prove this rational we must first locate the position and amount of protein adsorbed with increasing grafting density and molecular weight of the PEO chains (polymer coverage). Neutron reflectivity will allow us to relate the segment length density profile of the brush with the adsorbing protein molecule. With this information we hope to prove or dispel the current theories regarding protein adsorption at polymer brushes.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24079786
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24079786
Provenance
Creator Professor Richard Jones; Dr Andrew Parnell; Mr Warren Taylor
Publisher ISIS Neutron and Muon Source
Publication Year 2013
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2010-05-25T08:03:34Z
Temporal Coverage End 2010-05-28T14:28:58Z