Tuning the Molecular Exchange Kinetics of Self-Assembled Antimicrobial Peptide- Polymer Conjugates

DOI

Self-assembling antimicrobial peptides (SAAMPs) are promising candidates for antibiotic substitutes. The self-assembled structure provides proteolytic stability to the individual antimicrobial peptides. Since those need to target the bacterial membrane as unimers, the molecular exchange kinetics of the SAAMPs are of fundamental interest. In the proposed experiment we would like to investigate the exchange mechanism(s) of previously reported SAAMP-polymer conjugates. This will be achieved in a kinetic zero-average contras tscheme using time-resolved small-angle neutron scattering. By varying pH (assembly stability), temperature (exchange time) and sample concentration (collision-induced mechanisms), we will systematically study the molecular exchange pathways of SAAMPs, enabling the future tailoring in drug applications.

Identifier
DOI https://doi.org/10.5286/ISIS.E.RB1910106-1
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/103211091
Provenance
Creator Mr Nico Koenig; Professor Reidar Lund; Dr Najet Mahmoudi; Mr Luis Willner; Dr Lutz Willner
Publisher ISIS Neutron and Muon Source
Publication Year 2022
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences; Physics
Temporal Coverage Begin 2019-06-25T08:00:00Z
Temporal Coverage End 2019-06-28T08:15:49Z