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Engineering nanoparticles for protein therapeutics - quantifying membrane acc...
The self-assembly properties of lipid systems can be exploited to form lipid membranes with complex morphologies. These include membranes with a lattice-type internal structure... -
Structure of Cellulose Nanofibril Gels with Different Surfactants
This proposal is part of a project based on understanding the formation of gels in suspensions of partially oxidised cellulose nanofibrils and small amounts of additives, such... -
Understanding the microstructure of polymer blends used as control release co...
Solid oral dosage forms consist of polymer layer encapsulated drug-bound particles with a desired drug release profile e.g. pulsatile, controlled, delayed and targeted,... -
Effect of End Group on RAFT-Polymers for Lipid Nanodisc Stabilisation
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Previously we studied discs formed using... -
Structure of Cellulose Nanofibril Gels
This proposal is part of a new project based on understanding the formation of gels in suspensions of partially oxidised cellulose nanofibrils with small amounts of salt or... -
Changes of phospholipid aggregate morphology induced by phospholipase hydrolysis
We propose to look at the interaction of the aggregates two phospholipids form with two phospholipase (PL) enzymes, PLA2 and PLC, which hydrolyse different ester groups in the... -
SANS Study of the interaction of reconstituted model wheat waxes with non-ion...
The understanding of the plant wax-surfactant interaction process is crucial to the development of more effective pesticide and fungicide formulations, essential for improving... -
Response of Cellulose Nanofibril Gels to Shear
Partially oxidised cellulose nanofibrils have recently been found to form gels in the presence of small amounts of salt or surfactant. As cellulose is a renewable, sustainable... -
Understanding the liquid structure of binary ionic liquids
This proposal aims to extend our understanding of ionic liquid structure and determine the effect of a short and long alkyl chain length ionic liquid on the nanoscale... -
Insight into the atomic and intermediate level structure of spherical and rod...
Here we propose to look at the structure of two phosphocholine lipids, and their larger scale structures in aqueous solution. Depending on the length of the fatty acid chain in... -
Kinetics of amphotericin B interaction with model human and fungal cell membr...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents. The successful development of... -
Solution aggregation of lipopeptides: SANS structure determination
Lipopeptide surfactants are highly effective at reducing interfacial tension. However, there is a general lack of understanding of the relationship between their molecular... -
Effect of alloying on the misfit of Ni-Ni3Al-Ni3V alloys
The exceptional high temperature mechanical properties of Ni-base superalloys has resulted in their widespread use in high temperature applications. These alloys conventionally... -
Multiscale time-resolving study of solid state crystallisation from the mesom...
We will exploit the unique capability of Nimrod in the study of the long standing issue of polymer crystallisation. We focus on isotactic polypropylene which has been quenched... -
Determination of the Low Temperature Crystal Structure of Cobalt Adipate
This experiment will use high resolution neutron diffraction to investigate the crystal and magnetic structure of the cobalt adipate framework, Co(CO2(CH2)4CO2), at lower... -
Micelles of highly branched surfactants at the design limit
Results from this experiment will help develop to design 21st century surfactants (better performance with lower environmental consequences) by gaining essential information on... -
SANS studies of the micellar structures of mixtures of lauroyl-L-carnitine an...
As a new group of synthetic biosurfactants, the acyl-L-carnitines offer potential for different applications including working as edible biocides. Whilst extensive studies have... -
A study of hole injection efficiency for a model conjugated bilayer system
Polymer-based electronics have attracted huge interest due to their wide applicability to light emitting diodes, field effect transistors and photovoltaics. The aim of our... -
Effect of End Group on RAFT-Polymers for Lipid Nanodisc Stabilisation
Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Previously we studied discs formed using... -
Structure and encapsulation of additives in spray coated surfactant templated...
This proposal continues our work into surfactant templated films formed from surfactant/polyelectrolyte solutions. Recently we have been studying the encapsulation of...