Insight into the atomic and intermediate level structure of spherical and rod-like micelles in aqueous solutions

DOI

Here we propose to look at the structure of two phosphocholine lipids, and their larger scale structures in aqueous solution. Depending on the length of the fatty acid chain in a phopholipid molecule, different aggregates are formed, ranging from small spherical micelles to larger lamellar membrane bi-layers. We have chosen two small phosphocholine lipids, one with a 7-carbon and one with a 6-carbon fatty acid chain, where the latter forms spherical micelles while the former rod-shaped micelles, to investigate by neutron diffraction on NIMROD. Understanding the atomic level hydration concomitantly with the aggregated micellular structure in these systems has important implications in for a variety of practical applications such as membrane transport of drugs and drug delivery.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24079750
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24079750
Provenance
Creator Professor Jayne Lawrence; Dr Sylvia McLain; Ms Fabrizia Foglia
Publisher ISIS Neutron and Muon Source
Publication Year 2013
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2010-04-21T08:53:56Z
Temporal Coverage End 2010-04-26T12:47:56Z