261 datasets found

Skin is an important site for drug delivery. However skin, the stratum corneum which is mainly composed of mixture of lipids, cholesterols and fatty provide a barrier for drug...

In this proposal we investigate the adsorption of the key dispersant additive, sodium polyacrylate, used in colloidal systems using neutron reflection on aluminium oxide, with...

Seawater desalination process with reverse osmosis membrane has been widely used to supply high quality water. Over the past decades, despite considerable performance...

Organic solar cells (OPVs) are photovoltaic devices that can convert the energy from sunlight into electricity and have attracted much attention as a viable green energy source...

Oligo(ethylene glycol) self-assembled monolayers (SAMs) effectively prevent the adsorption of proteins from biological media. Despite the importance of this effect for...

gemini surfactants are essentially two surfactants joined by a linking chain. We have extensively explored cationic geminis at the air/water interface and they exhibit a range...

As part of a project concerning the fate of nanoparticles in the body we have been studying the kinetic and competitive (or cooperative) aspects of protein adsorption. HSA is...

Surfactants usually form a single layer of molecules at the surface of water. We have shown that under certain conditions more than one layer may form. in which case the system...

We ask for 3 days of beam time on CRISP to study the absorption and desorption of hydrogen and deuterium in two Mg/Ti multilayer samples. Our specific objective is to understand...

Drug delivery through skin is an important delivery route. However, the outermost layer of the skin provides a formidable barrier to dermal absorption and penetration for...

We have found it possible to deposit mesostructured surfactant templated polymer thin films on solid substrates. To date the majority of work has used hexadecyltrimethylammonium...

We will use neutron reflectivity measurements of lipopolysaccharide (LPS) layers at the air-water interface to help develop a realistic mimetic for the periphery of bacteria...

Perfluoroalkyl substances (PFASs) are fully fluorinated, stabile, and surface-active compounds. They contain both a hydrophobic fluorinated carbon chain and an ionizable...

Cyclic peptide-polymer nanotubes can readily self-assembly into long nanotubes, and are being extensively studied for drug delivery applications. As such, understanding how...

We have recently characterised a surface wetting transition for a low molecular weight oligomer in a high molecular weight rubbery polymer. Although weak surface segregation of...

The stratum corneum which is mainly composed of mixture of lipids, cholesterols and fatty provide a formidable barrier for drug penetration through skin. In this proposal, we...

Tuning the interactions between different surfaces has technological benefits in areas such as adhesion, compatibilisation and nano-actuators. We shall study the interaction...

Clupeine is isolated from herring and is an example of a protamine, which are cationic antimicrobial peptides occurring in the sperm cells of some fish. Protamines are active...

Neutron reflection will be used to reveal the structural changes from different inner membrane leaflet models upon interacting with a group of antimicrobial lipopeptides with...

The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers...