612 datasets found

Recently (RB19100102) we have discovered that floating bilayers composed of fluid phase lipids can be produced by deposited vesicles onto charge modified oligo(ethylene...

Objectives of this proposal aim to shed light on how adsorption processes such as protein A chromatography, used to purify biologics, affect protein propensity for aggregation....

The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the...

Tissue Factor (TF) is a membrane protein located on the cell surfaces of extravascular cells. TF activity is fundamental for normal homeostasis- the physiological process which...

Neutron reflection will be used to investigate the normal composition profile in thin films of blends of electron-donor poly(alkyl thiophene) and the electron-acceptor...

This proposal presents to directly measure ¿bridging¿ of anionic surfactants on an anionic surface through multivalent ions from water under well-controlled conditions (pHs and...

We request 5 days on Sandals to study the interactions of the neurotransmitters dopamine, L-dihydroxyphenylalanine and norepinephrine in aqueous solution. The interactions of...

The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial...

PVA film is widely used as a non-toxic water soluble polymer. This proposal relates to its use in unit dose detergent pouches where plasticised PVA film stores a concentrated...

We propose to perform combined measurements of neutron reflectometry (NR) and impedance spectroscopy (IS) to investigate the structure/function relationship of tethered bilayer...

The Na+/H+ exchanger isoform 1 (NHE1) is a transmembrane protein with the primary function of regulating the pH in the cytosol by exchanging one proton with one Na+ ion. The...

Gold provides a high quality surface on which to arrange biomolecules such as proteins since we can use cysteine amino acids to deliver gold thiol chemical bonds which can...

The bacterial cell envelope is one of the best targets for antimicrobial development. It is this envelope that harbours the instruments of microbial warfare, preventing its...

In late 2017, T-cell therapy became the first gene therapy to have been approved by the US FDA and in 2018 approved for use in the UK. From the clinical data presented thus far,...

We ask for 3 days of beam time on Inter/SURF to study the adsorption and adlayer characteristics of avidin on Ti surfaces, relevant for biomedical applications, such as...

Engine oils provide lubrication to moving components in engines, improving vehicle lifespans whilst reducing emissions and fuel consumption by minimising friction. A common...

Protein-membranes interactions are fundamentally important to biological function. We have developed advanced models of the Gram negative bacterial outer membrane and have...

Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element...

Many drugs are both poorly water-soluble (hydrophobic) and lipophilic in nature and are therefore incorporated into surfactant micelles and monolayers. As the incorporation of...

Recently the intracellular domain (ICD ) of the Na+/H+ exchanger isoform 1 (NHE1), is a transmembrane protein, has been identified as an intrinsically disordered protein....