A comparative NR study of interaction of short designed antimicrobial peptides to accurate gram negative and red blood cells model membranes

DOI

The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial agents. One class of promising antimicrobials found in nature are Antimicrobial Peptides (AMP’s) [1]. In contrast to most existing therapeutic antimicrobials, and so it is thought that resistance would be far more difficult to develop to AMP’s. We have designed a novel class of AMP's with the general sequence G(IIKK)nI-NH2, with n-the number of coils of α-helix (n=2-4). In a recent experiment we have studies the interaction of these peptides with floating bilayers intended to mimic gram negtive of eukaryotic membranes, and obesrved changes to membrane structure on binding. In this experiment we wish to extend this preliminary work by studying the concentration dependence of peptide interaction with membranes.

Identifier
DOI https://doi.org/10.5286/ISIS.E.83553013
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/83553013
Provenance
Creator Dr Andrew Caruana; Mr Haoning Gong; Mr Charles Smith; Dr Arwel Hughes; Professor Jian Lu; Miss Daniela Ciumac; Dr Luke Clifton
Publisher ISIS Neutron and Muon Source
Publication Year 2020
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering
Temporal Coverage Begin 2017-02-16T08:00:00Z
Temporal Coverage End 2017-02-20T00:00:00Z