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Probing membrane localisation of molecular rotors
A number of important biological processes, such as intracellular transport and signal transduction depend on the viscosity and the distribution of microdomains in cells. We... -
Purothionin binding to model fungal lipid membranes
Purothionins and defensins are basic, amphiphilic, cysteine-rich and low molecular weight plant defence proteins. These proteins are active against a broad range of... -
SANS study of lipid-based nanocarriers as inhaled drug delivery systems for a...
The present project aims to achieve a more detailed structural characterization by SANS of Solid Lipid Nanoparticles (SLN) and liposomes in a perspective of an inhaled anti... -
Ordering of water molecules in water/amino acid mixtures
The obvious role played by water dynamics in the biological movements and reactions has stimulated huge experimental efforts during last years. However, biological materials are... -
Antimicrobial peptide-loaded nanogels and their interaction with lipid bilayers
Due to increasing antibiotic resistance, bacteria membrane disrupting antimicrobial peptides (AMPs) are of increasing interest as alternatives to classical antibiotics. AMPs are... -
Mimicking Pathogens : Floating Gram Negative Bacterial Membranes Containing t...
Recently we have been able to show two advances in the creation of realistic models of the Gram negative bacterial outer surface for use in biophysical and structural studies.... -
The effect of membrane fluidity on the interaction of antimicrobial proteins ...
Protein-lipid\membrane interactions are fundamentally important to biological processes. We have examined the role protein hydrophobicity in protein-membrane interactions... -
Modelling Protein-Protein Interactions and the Hofmeister Effect
Nimrod is a unique instrument that bridges atomic resolution solution scattering with small angle scattering. The opportunity therefore exists to probe both the microscopic... -
A study of hole injection efficiency for a model conjugated bilayer system
Polymer-based electronics have attracted huge interest due to their wide applicability to light emitting diodes, field effect transistors and photovoltaics. The aim of our... -
Structure of Confined Mucin Films
Nowadays, a significant research effort is devoted to understand and mimic biological lubricants which, in contrast to most man-made lubricants, are based on water. It has been... -
Pair distribution function analysis of stacking disorder in ice
Very recently, the metastable cubic ice phase was renamed to stacking-disordered ice (ice Isd) in order to emphasise the fact that this form of ice contains not only cubic... -
Model Amphiphilic Deep Eutectic Liquids
Deep eutectic liquids (DELs) - mixtures of high melting-point solids that form stable liquids near room temperature ¿ have recently emerged as a new class of novel solvents with... -
Anionic surfactant induced desorption of cationic surfactants from anionic su...
In this proposal, we request beamtime to study the unexpected behaviour of a strongly bound bilayer of the cationic surfactant didodecyldimethylammonium bromide on the anionic... -
Short peptide self-assembly and pesticide solubilisation in binary surfactant...
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Organic Additives Adsorption at the Steel-Paint Interface and Its Effects on ...
Numerous additives have been added to paints and coatings to improve adhesion, and prohibit corrosion if the substrate is reactive to its surrounding environs. The adsorbates in... -
Muon probes of hydrogen-bond network in supercooled water
Muon diamagnetic fraction in liquid water is known to decrease with decreasing temperature probably because its formation mechanism results from the structural alternation and... -
Pinning down pinholin: a structural mechanism to explain how peptide adsorpti...
We will use specular and off-specular neutron reflectivity to provide a structural mechanism for the way in which the amphipathic peptide pinholin controls bacterial cell lysis... -
The Mechanism of Bam Mediated Outer Membrane Protein Folding
The proteins of the outer membrane of Gram-negative bacteria are critical for bacterial survival,from providing basic physiological functions, to impairing virulence and... -
Interaction of amino acid based biosurfactants with model lipid bilayers
N-acyl amino acids are surfactants with attractive applications in different technological fields. They are referred to as mild surfactants because they are commonly considered... -
A study of the role of divalent cations in the stability of smooth LPS in out...
The Outer Membrane (OM) is found in bacteria which cause plague, cholera & Legionnaires disease. It is important as; a barrier to antibiotics & the site of...
