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Concerted proton tunnelling in ordinary ice
In a recent study we showed, by incoherent elastic and quasielastic neutron scattering measurements, the existence of non-harmonic motion of hydrogen in ordinary ice. The motion... -
Neutron diffraction from polyunsaturated multibilayer membranes containing a ...
Polyunsaturated fatty acids (PUFAs) are essential dietary fats that have been proposed to reduce the risk of cardiovascular and auto-immune diseases, arthritis and cancer. PUFA... -
Examining the Structural Changes of a Central Nervous System Neurotransmitter...
GluR0 is a glutamate sensitive potassium ion channel from the cyanobacterium Synechocystis which has been identified via primary structural sequencing to be similar to... -
Membrane interactions of virus-like silica nanoparticles as antimicrobial pep...
As a result of an increasing number of bacteria developing resistance against antibiotics, antimicrobial peptides (AMPs) are currently attracting significant interest. However,... -
Formation of asymmetric free-standing bilayers with lipopolysaccharide in the...
We have recently improved the stability and coverage of free standing bilayers by the use of a supporting thiolipid layer on gold. The system has been investigated on POLREF and... -
Adsorption of Monoclonal Antibodies at the Solid/liquid Interface
We propose to use neutron reflection to study the interfacial adsorption of 2 novel bispecific therapeutic antibodies at the silicon oxide/water interface. To enpower each of... -
Interactions of polyfluorinated substances with a phospholipid bilayer
Poly- and perfluoroalkyl substances (PFASs) have been used in various industrial applications and consumer products, but have received increasing global concern due to their... -
Probing Ion Binding to Micelles ¿ Investigating the Hofmeister Series
This proposal continues our research on ion binding to surfactant micelles. Our recent work demonstrates that the details of water structure around micelles are now accessible... -
Probing membrane localisation of molecular rotors
A number of important biological processes, such as intracellular transport and signal transduction depend on the viscosity and the distribution of microdomains in cells. We... -
Purothionin binding to model fungal lipid membranes
Purothionins and defensins are basic, amphiphilic, cysteine-rich and low molecular weight plant defence proteins. These proteins are active against a broad range of... -
SANS study of lipid-based nanocarriers as inhaled drug delivery systems for a...
The present project aims to achieve a more detailed structural characterization by SANS of Solid Lipid Nanoparticles (SLN) and liposomes in a perspective of an inhaled anti... -
Ordering of water molecules in water/amino acid mixtures
The obvious role played by water dynamics in the biological movements and reactions has stimulated huge experimental efforts during last years. However, biological materials are... -
Antimicrobial peptide-loaded nanogels and their interaction with lipid bilayers
Due to increasing antibiotic resistance, bacteria membrane disrupting antimicrobial peptides (AMPs) are of increasing interest as alternatives to classical antibiotics. AMPs are... -
Mimicking Pathogens : Floating Gram Negative Bacterial Membranes Containing t...
Recently we have been able to show two advances in the creation of realistic models of the Gram negative bacterial outer surface for use in biophysical and structural studies.... -
The effect of membrane fluidity on the interaction of antimicrobial proteins ...
Protein-lipid\membrane interactions are fundamentally important to biological processes. We have examined the role protein hydrophobicity in protein-membrane interactions... -
Modelling Protein-Protein Interactions and the Hofmeister Effect
Nimrod is a unique instrument that bridges atomic resolution solution scattering with small angle scattering. The opportunity therefore exists to probe both the microscopic... -
A study of hole injection efficiency for a model conjugated bilayer system
Polymer-based electronics have attracted huge interest due to their wide applicability to light emitting diodes, field effect transistors and photovoltaics. The aim of our... -
Structure of Confined Mucin Films
Nowadays, a significant research effort is devoted to understand and mimic biological lubricants which, in contrast to most man-made lubricants, are based on water. It has been... -
Pair distribution function analysis of stacking disorder in ice
Very recently, the metastable cubic ice phase was renamed to stacking-disordered ice (ice Isd) in order to emphasise the fact that this form of ice contains not only cubic... -
Model Amphiphilic Deep Eutectic Liquids
Deep eutectic liquids (DELs) - mixtures of high melting-point solids that form stable liquids near room temperature ¿ have recently emerged as a new class of novel solvents with...
