Due to increasing antibiotic resistance, bacteria membrane disrupting antimicrobial peptides (AMPs) are of increasing interest as alternatives to classical antibiotics. AMPs are easily degraded in the chemical and enzymatic environment in the body, requiring a protecting drug delivery system (DDS) to ensure effect after administration. Nanogels, designed to be biocompatible, provide a water-rich environment where the AMP can maintain its function. Preliminary work has shown that that combining the AMP with a nanogel improves the membrane disruption. We propose to study a nanogel-AMP formulation and it's interaction with a bacteria model lipid bilayer to elucidate the mechanism of action for this system. This data will be key to understanding the observed synergistic effect between nanogel and AMP that has to date proved impossible using our lab based techniques.