129 datasets found

Solid oral dosage forms consist of polymer layer encapsulated drug-bound particles with a desired drug release profile e.g. pulsatile, controlled, delayed and targeted,...

Zwitterionic lipids such as phosphatidylcholine (PC) are major components of the membranes that compartmentalize organisms. Although there is a large literature on PC, cationic...

Coacervates have been studied for a long time for their unusual properties: they are dense networks of charged polymers that are soluble in water. Instead of flocculating when...

It is proposed to use small-angle neutron scattering (SANS) to investigate in detail the binary phase diagram between 1-ethyl-3-methylimidazolium...

In this part of proposed work, we wish to explore how antibiotics minocycline and tetracycline interact with model lipid bilayers in the form of SUVs, mimicking key features of...

The separation of particular lipids in cell membranes into liquid ordered and liquid disorder regions is thought to have a major influence of the functioning of membrane...

Bacterial endotoxins, or lipopolysaccharide (LPS), released from the gram negative bacterial membrane, form different aggregates in solution which morphology depends on the type...

Increased environmental pressures and awareness is promoting a major drive towards an increased use of biosurfactants to produce more biosustainable and biodegradable consumer...

The aim of this proposal is to study the structure of hydrogel systems formed from fluorenylmethyloxycarbonyl (FMOC) protected peptides, via the use of nitric oxide radicals....

This proposal involves manipulating the curvature of aggregated polar materials in supercritical CO2 (scCO2) by tuning the mixing ratio of fluorocarbon (FC) and hydrocarbon (HC)...

Mucoadhesion is the ability of polymers to adhere to mucosal membranes in the human body and provide a temporary retention. It has been widely used to develop polymeric dosage...

Poly(vinyl alcohol) is a biocompatible water-soluble polymer of great interest thanks to its large-scale applications for production of drug-delivery systems, sensors or...

The microscopic origins of strain softening (Payne Effect) are vital to our understanding of energy dissipation in vehicle tyres. This proposal builds on our recent SANS...

Atherosclerosis is the primary cause of death in westernized societies. Clinical indicators include not only the net lipoprotein concentration but also the ratio between the...

We propose to look at the interaction of the aggregates two phospholipids form with two phospholipase (PL) enzymes, PLA2 and PLC, which hydrolyse different ester groups in the...

A shift towards antibody-based cancer treatments has occurred due to their ability to provide targeted cancer treatment with fewer negative side effects than traditional...

The objective is to refine current understanding about the mechanism of hydrotropy with respect to polarity and electrostatic character of hydrotropes and hydrophobic solutes...

Polyurethane foams (PUFs) are commonly prepared by mixing Pluronic type copolymers and isocyanate reactive monomers in the presence of additives e.g. catalysts, blowing agent...

This proposal involves manipulating the curvature of aggregated polar materials in supercritical CO2 (scCO2) by tuning the mixing ratio of fluorocarbon (FC) and hydrocarbon (HC)...

Associative polymers have a very important role as rheological modifiers, due to their ability to form interconnected networks of hydrophobic domains. Additionally,...