Effect of serum and electrolyte on the structure of nanoemulsions intended for the treatment of cancer

DOI

Nanoemulsions (NE) i.e. nanoparticles containing a fluid lipid or oil dispersed in water and stabilized by a surfactant particles have attracted considerable attention as vehicles for the delivery of poorly-water soluble drugs. We have recently developed a series of novel nanoemulsions containing either trilaurin or soybean oil as the disperse phase and stabilised by the non-ionic surfactant, oleyl polyoxethylene (10) ether. In order to use the NE as vehicles for the delivery of cancer it is essential to understand the effect of electrolyte and plasma proteins on the structure of the NE. The proposed SANS study will therefore determine the effect of electrolyte and plasma proteins on the properties of the NE. The insight provided by the study should provide a better understanding of the potential of NE as vehicles for drug delivery.

Identifier
DOI https://doi.org/10.5286/ISIS.E.81735739
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/81735739
Provenance
Creator Ms Orathai Loruthai; Miss Simona-Vyara Kolarova; Dr Sarah Rogers; Professor Jayne Lawrence; Miss yanan shao; Dr Dave Barlow; Dr Ann Terry
Publisher ISIS Neutron and Muon Source
Publication Year 2019
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Natural Sciences
Temporal Coverage Begin 2016-07-22T08:00:00Z
Temporal Coverage End 2016-07-24T08:00:00Z