Chain exchange mechanism of complex coacervate core micelles

DOI

Complex coacervates have been studied for a long time for their medical applications and unusual physical-chemical properties: they are dense networks of poly-electrolytes, that dissolve instead of flocculating when exposed to high salt concentrations. Despite being dense, they are fully permeable to water, yet they are capable of strongly binding heavy metal ions or large (bio-)molecules, making them useful as drug carriers. By modifying them to form micelles, the micelle cores become small coacervate networks; Complex Coacervate Core Micelles (C3Ms). Unlike gels, they are dispersed into solution easily and have an enormous active surface area. The form and structure of C3Ms are quite well known, but the exchange mechanism of polymers between micelles is unknown. By performing contrast decay time-resolved SANS, we will determine if polymers migrate separately or in charge-neutral pairs.

Identifier
DOI https://doi.org/10.5286/ISIS.E.73947619
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/73947619
Provenance
Creator Dr Wim Bouwman; Dr Sarah Rogers; Dr Ilja Voets; Mr Jurrian Bakker; Dr Clément Guibert; Dr Ad van Well
Publisher ISIS Neutron and Muon Source
Publication Year 2019
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Chemistry; Natural Sciences
Temporal Coverage Begin 2016-03-11T09:00:00Z
Temporal Coverage End 2016-03-13T09:00:00Z