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Floating Bilayer Mimics of the Gram Negative Bacterial Outer Membrane
The gram-negative bacterial membrane is of extreme medical importance. The two main lipid components of the outer membrane are lipopolysaccharides (LPS's) and DOPE. We will... -
The Kinetics of Ethanol Adsorption into Cholesterol Rich Bilayers
In a recent experiment carried out on SURF we have shown that on addition of ethanol to a DPPC model membrane, the anaesthetic initially diffuses to the bilayer surface followed... -
Fluorination Effects at Liquid Crystal Surfaces
The adsorption of a liquid crystal dopant to a surface can have a significant impact on its properties such as electro-optic response and lubrication. Both the interesting... -
The Interaction of wild-type and mutant Puroindoline B with Model Bacterial M...
Bacterial and fungal infections of cereal crops pose a considerable risk to global food security. Typically plant pathogens are controlled through the use of chemical agents... -
Membrane interactions of a viral scission protein
Influenza virus is a pathogen of great medical importance that causes seasonal epidemics and sporadic pandemics. Among the least understood events of the influenza virus... -
Developing a generic gravimetric method to determine the composition of films...
We propose to develop a new and generic, multi-probe technique to characterize the mass, and changes in mass, of material probed in a NR experiment. This methodology will be... -
Polymer-surfactant films containing glucose sensors and structure directing p...
This proposal continues our research on mesostructured surfactant templated polymer films. The films are robust and form spontaneously at the air-water interface. Recent... -
Can surfactants be pushed out of polymer layers by applying compression?
For many applications such as paints, foods and drug formulations, aggregation of colloidal particles is prevented by combining polymer and surfactant adsorption. Key to this... -
Antibody-polysorbate surface interactions
Of concern to the bioprocessing industry is the manner in which polysorbates included in solution formulations of antibodies affect the kinetics and equilibrium state of... -
Effect of alkyl chain length on the adsorption of n-alkyl phosphocholine surf...
This proposal relates to the study of adsorption of n-dodecyl phosphocholine (C12PC) at the oil-water interface. The thickness of the adsorbed monolayers measured for dC12hPC... -
Composition depth profiling of novel spray-coated plastic solar cell materials
We propose to study a range of new lower energy gap organic photovoltaic (OPV) materials deposited by spray coating using neutron reflectivity. The new materials to be studied... -
Surface adsorption in multi-component biosurfactant-surfactant mixtures
This proposal is about the development of sustainable detergency based formulations, based on the blending of biosurfactants with conventional surfactants, and is part of a CASE... -
Kinetics of Protein Adsorption on well-characterised polymer brushes
We wish to develop a rational understanding of the mechanisms underlying the way water soluble polymer brushes - in particular those of polyethylene oxide/polyethylene glycol -... -
Part B: Binding behaviour of PAMAMs G5 and G4.5 to zwitterionic and anionic l...
Polymers are commonly used in drug delivery to create dosage forms that enable delivery of the active ingredient to the site of action within the body. Towards controlled drug... -
Interfacial structures between Nafion and Platinum under controlled electroch...
We wish to propose a neutron reflectivity (NR) experiment for a Nafion/platinum interface under controlled electrochemical potential, because NR is the only technique to study... -
Probing Solvation and Segregation in Multilayer Conducting Polymer Films
Tuning the colour of electrochromic conducting polymers can be achieved by layer upon layer deposition of multiphase components. This approach can offer advantages over other... -
Organisation of Outer membrane protein F at the air/liquid interface
Crystallisation of membrane proteins as a precursor to high resolution structural studies is a significant research bottleneck. We are investigating alternative methods to... -
Structural Analysis of Water Multilayer in Lamellar Mesoporous Materials
Although the preparation of lamellar mesoporous materials (LMMs) is very difficult due to collapsion in removing the templating surfactant, we have successfully synthesized a... -
Sub-micron structure of conjugated polymer interfaces
There are two contributions to the rms roughness of a polymer-polymer interface; i) the so-called ¿intrinsic interfacial width¿ due to mixing of the polymers at a molecular...