103 datasets found

Gram negative bacteria cause a wide range of diseases including meningitis, bubonic plague, gonorrhoea, diarrhoea, Legionnaires' disease and cholera. Their outer membrane...

In a series of neutron spin-echo experiments (NSE) on the proteins alcohol dehydrogenase (ADH) and phosphoglycerate kinase (PGK) large scale large amplitude domain motions with...

Neutron reflection has been successfully used to measure the conformation of proteins adsorbed at the oil/water interface. However, in several such experiments, hexadecane has...

Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation....

Polymer-protein conjugates have been designed to deliver an appropriate target growth factor to promote a more rapid healing of chronic wounds, an incredibly important area for...

The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the...

Hydrophobins are secreted fungal proteins and are small lipopeptide biosurfactants. They are strongly surface active and self-assemble at interfaces. Their unique film forming...

Lipid membranes provide a sensitive platform for a variety of biological functions, and membrane lipid distributions are carefully regulated. In this project we plan to study...

IgG antibody represents one-third of new drugs currently in development. We will unravel the solution structures of the Fab and Fc fragments within IgG. Following our earlier...

The aim of this collaborative proposal is to unravel micro- and nano-structures underlying unusually high solution viscosities from mixed surfactant systems. SANS is a unique...

Following our previous study of adsorption of Fc, Fab and the constituent mAb COE-3, we continue to explore how two bioengineered mAbs adsorb at the oil/water interface by...

Lipopeptide surfactants are a group of interesting biosurfactants due to their natural origin and their high effectiveness at reducing interfacial tension. However, there is a...

This proposal constitutes part of our ongoing study towards understanding the adsorption of collagen based polypeptide and its interaction with ionic surfactants at the...

Approved proposal under the ICRD Scheme Proposal ICRD0003

The main objective of the present study is to gain an understanding of the nature of the interaction of ¿phospholipid membranes¿ with small, interfering RNA (siRNA) in the...

Bio-surfactants that can be harvested from micro-organisms are of particular interest, because these can potentially be harvested in high yield and at low cost. In this category...

Antibiotic resistance is pathogenic bacteria is a major clinical problem. Resistance to all antibiotiotic classes, currentl yin clinical use, has been reported. By contrast, the...

N-acyl amino acids are surfactants with attractive applications in different technological fields. They are referred to as mild surfactants because they are commonly considered...

We grafted 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer brush from the silicon wafer surface through Cu (0) mediated controlled radical polymerization (CuCRP) to mimic...

This proposal seeks to gain an understanding of the adsorption and desorption behaviour of a redox membrane protein, cytochrome c, in electrochemical cells using different anode...