-
SANS contrast measurements on important protein/DNA interactions from RCaH
This proposal is to perform SANS contrast measurements on three protein/DNA interactions currently worked on at the Research Complex at Harwell. This is part of an ongoing... -
Anisotropic Displacement Parameters and Diffuse Scattering in Graphite
The accurate description of van-der-Waals forces within DFT is currently one of the most active areas of research in computational physics and chemistry. In the case of soft... -
PROBING THE NEAR AND INTERMEDIATE RANGE NANOSTRUCTURE OF DNA/PEPTIDE HYDROGELS
The near- and intermediate-range order within peptide and peptide/DNA hydrogels will be probed across the q range available on NIMROD. Samples will be prepared in H2O/D2O... -
Interaction of the nucleic acid, DNA, with a model biomembranes of varying ri...
In this experiment we aim to investigate, using neutron reflectometry in combination with contrast variation, the intermolecular interaction between the nucleic acid, calf... -
Conformational changes on interaction of cytochrome c with lipid monolayers.
The main objective of the present work is to gain an understanding of the interaction of the cationic protein, cyt c with anionic lipid membranes. This objective will be... -
Molecular interactions between phospholipid monolayers and dimethylsulphoxide
Neutron reflectivity will be employed to investigate the interaction between dimethylsulphoxide and monomolecular films of phosphatidylcholine. The monolayer will be used as a... -
Structure of siRNA containing delivery vehicles: effect of serum
Complexes prepared from cationic, dichain lipid (L) vesicles and negatively charged siRNA (R), with and without positively chargely targeting peptides (P) known as LR or LPR... -
Investigation of zwitterionic surfactant, Ca2+ and bio-polymer interactions
We are currently investigating the formation and structure of surfactant-templated polymer films comprised of cat-anionic surfactant mixtures and a variety of polymers. As we... -
Kinetic Study of the Mechanistic Complexation Process Between DNA and Cationi...
We propose to use the new SANS2d to study the dynamic structural evolution in the couse of the formation of DNA-cationic polymer complexes. The dynamic process and the mixing... -
Structure-function studies of Replication Protein A, a crucial player in geno...
Replication protein A (RPA), the eukaryotic ssDNA binding protein, is a heterotrimeric protein required for almost all aspects of cellular DNA metabolism. RPA binds... -
PROBING DRUG PHARMACODYNAMICS BY QENS: THE EFFECT OF CISPLATIN-LIKE ANTICANCE...
This dataset has no description
-
RESUBMISSION : DNA hybridisation-mediated vesicle fusion - kinetics and fate ...
Controlled vesicle fusion has major advantages in diagnostic and drug delivery applications. We have designed a DNA hybridisation-based assay for directed fusion of vesicles... -
Investigation of zwitterionic surfactant templated bio-polymer films as senso...
We have found it possible to deposit mesostructured surfactant templated polymer thin films on solid substrates. To date the majority of work has used hexadecyltrimethylammonium... -
Surfactant aggregation in magnetic ionic liquids
This proposal aims to explore aggregation behavior of common surfactants in magnetic ionic liquids (MILs) and to investigate the effect of a magnetic field on aggregate size,... -
Probing the internal structure of gene delivery vehicles using contrast varia...
Gene delivery vehicles, known as LPD complexes, prepared from mixing cationic lipid vesicles (L) with cationic peptide (P) and DNA (D) have proven to be very effective at... -
Single Domain pH-Driven DNA Nanoswitch
DNA is an extremely versatile building material for the development and assembly of functional nanostructures and nanodevices. There are numerous examples of DNA based... -
Interactions between a mixture containing two cationic polyelectrolytes and a...
Recently there has been a vast expansion in understanding about the interactions between oppositely charged polyelectrolyte/surfactant mixtures. The use of neutron reflectometry... -
The calcuim mediation interaction of DNA with monolayers of DSPC and DOPE
The main objective of the present work is to complete some work aimed at gaining an understanding of the interaction of phospholipid membranes containing the neutral helper... -
Molecular architecture of monolayers formed by novel sterol-modified phosphol...
A family of sterol-modified glycerophospholipids (SML) have been synthesized in which the sn-1 or sn-2 position is covalently attached to cholesterol and the alternative... -
Proton Zero Point Energy Effects on the Folding of Proteins
Earlier experiment at ISIS have shown that water responds to the distortion of the hydrogen bond network by delocalizing some of the protons in the vicinity of the defects. That...
