38 datasets found

Lipidic cubic nanoparticles (LCNPs) have been extensively studied as therapeutic agents and delivery systems due to their biocompatibility, ease of drug encapsulation and...

A number of important biological processes, such as intracellular transport and signal transduction depend on the viscosity and the distribution of microdomains in cells. We...

Polymers are commonly used in drug delivery to create dosage forms that enable delivery of the active ingredient to the site of action within the body. Towards controlled drug...

Gram-negative bacteria, which cause a variety of diseases including meningitis, plague, sepsis and food poisoning, are becoming increasingly antibiotic resistant. One reason is...

Hydroxyl radicals may be used as disinfection agent in the advanced oxidation processes or tertiary treatment of waste and occasionally drinking water. In this exploratory work,...

The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the...

Polymer-protein conjugates have been designed to deliver an appropriate target growth factor to promote a more rapid healing of chronic wounds, an incredibly important area for...

The main objective of the present work is to gain an understanding of the interaction of the cationic protein, cyt c with anionic lipid membranes. This objective will be...

In a recent experiment carried out on SURF we have shown that on addition of ethanol to a DPPC model membrane, the anaesthetic initially diffuses to the bilayer surface followed...

The Outer Membrane (OM) is found in bacteria which cause plague, cholera & Legionnaire?s disease. It is important as; a barrier to antibiotics & the site of...

The main objective of the present study is to gain an understanding of the nature of the interaction of ¿phospholipid membranes¿ with small, interfering RNA (siRNA) in the...

The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers...

One of the major challenges in the fight against antimicrobial resistance is the development of antimicrobial compounds that selectively disrupt bacterial membranes and leave...

Bacterial and fungal infections of cereal crops pose a considerable risk to global food security. Typically plant pathogens are controlled through the use of chemical agents...

Surfactants usually form a single layer of molecules at the surface of water. We have shown that under certain conditions more than one layer may form. in which case the system...

Cubosomes and hexosomes are particles with internal liquid crystal structures of the bicontinuous cubic or reverse hexagonal nanostructures respectively. The nanostructure...

This proposal seeks to identify and characterise the adsorption of primary linear amides that adsorb to the surface from the bulk of a polymer melt. These layers are...

This proposal relates to the structural studies of Di-stearoyl and di-palmitoyl Polyethylene glycol derivates as a function of the PEG head group at the air-water and the...

The mechanism of general anaesthetic action is poorly understood despite their widespread use. It is hoped that investigating the interaction of anaesthetics with lipid bilayers...

Bacteria growing resistant to common antibiotics is a growing problem and research in new types of medicines which do not induce resistance is therefore very important. Novel...