Effect of pH on the complexation behaviour between Pluronic micelles, drugs and β-cyclodextrins

DOI

Pluronic micelles are attractive candidates as drug carriers. Despite the abundance of data on their association with various drugs, there is, in contrast, very little characterisation of the micellar structural changes associated with drug encapsulation; this information is fundamental, since it is directly linked to drug loading efficiency and release profile. Following previous studies on LOQ using a range of related drugs, it appears that the localisation of the drug inside the micelles is directly related to its charge. This requires further studies in pH-controlled conditions. In addition, we have proposed the use of ß-cyclodextrin as a trigger to break-up the micelles and release the drug; this process leads to competitive three-way interactions, as ßCD can also interact with the drugs. Therefore, mixtures in the presence of ßCD will also be studied in the same conditions of pH.

Identifier
DOI https://doi.org/10.5286/ISIS.E.24079343
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24079343
Provenance
Creator Dr Cecile Dreiss
Publisher ISIS Neutron and Muon Source
Publication Year 2013
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2010-06-25T08:16:10Z
Temporal Coverage End 2010-08-12T09:44:50Z