Characterization of melanoma TILs and identification of mimotope peptide antigens

We sequenced TCRs of tumor-infiltrating T cells to characterize the T cell response following combination immunotherapy of murine melanoma. After identifying a dominant antigen recognized by expanded TILs, we then used yeast displayed peptide-MHC libraries to identify mimotopes to enhance the T cell response.

Identifier
Source https://data.blue-cloud.org/search-details?step=~0125676E6274C5ACADE556DB069B84588ABCCD7EAAD
Metadata Access https://data.blue-cloud.org/api/collections/5676E6274C5ACADE556DB069B84588ABCCD7EAAD
Provenance
Instrument Illumina MiSeq; ILLUMINA
Publisher Blue-Cloud Data Discovery & Access service; ELIXIR-ENA
Publication Year 2024
OpenAccess true
Contact blue-cloud-support(at)maris.nl
Representation
Discipline Marine Science
Temporal Coverage Begin 2020-10-01T00:00:00Z
Temporal Coverage End 2022-02-26T00:00:00Z