This dataset contains hydrographic observations from Sermilik Fjord in SE Greenland, collected in August 2015 aboard the RV Adolf Jensen, including discrete data derived from water sample analyses and corresponding CTD sensor data. CTD data were collected using a Seabird 25Plus Sealogger equipped with a SBE 43 dissolved oxygen sensor, a Satlantic PAR LOG sensor, and a Wetlabs / Seabird ECO Triplet (chlorophyll-a and CDOM fluorescence, as well as backscattering at 700 nm). Discrete samples for nitrate, phosphate, silicate, and ammonium, were filtered through a sterile 0.22 µM Sterivex filter using standard protocols and kept frozen at -20 °C for later analysis at the Woods Hole Oceanographic Institution Nutrient Analytical Facility. Dissolved nutrient concentrations were quantified using a SEAL AA3 four-channel segmented flow analyzer.