On the structure and composition of non-lamellar lipid-based liquid crystalline nanoparticles


To better understand the properties of non-lamellar liquid crystalline nanoparticles (LCNP) as delivery vehicles, it is crucial to understand their internal structure and the location of the different compounds. To date, there are only a very limited number of studies that have aimed to address these issues. The aim of this work is to determine the location of the stabilizer within the particle consisting of phosphatidylcholine/glyceroldioleate/d- or h-polysorbate 80 (stabiliser): 1. Is the content of P80/lipid ratio in the particle the same as the total concentration? Is the P80/lipid ratio in the particle affected by the lipid composition and the amount of added P80? 2. What is the location of the stabilizer P80 within LCNP, that is, how much is in the shell and how much is located in the core? How is it affected by the lipid composition and the amount of added P80?

DOI https://doi.org/10.5286/ISIS.E.24090579
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/24090579
Creator Dr Fredrik Tiberg; Professor Tommy Nylander; Dr Maria Wadsäter; Dr Justas Barauskas; Dr Bob Thomas
Publisher ISIS Neutron and Muon Source
Publication Year 2016
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Resource Type Dataset
Discipline Photon- and Neutron Geosciences
Temporal Coverage Begin 2013-05-26T07:58:04Z
Temporal Coverage End 2013-05-28T09:12:56Z