The pharmaceutical industry has been described as being 'in a period of crisis' as the number of drug approvals relative to most major pharmaceutical companies Research and Development spending is increasing while the number of new medical entities is steadily decreasing. Coupled with the fact that many drug patents for top-selling drugs are soon to expire ensures that the pharmaceutical industry will soon be entering a crisis. Understanding how drugs interact with a physiologically relevant environment will likely prove to be crucial in the future of effective drug design in the future. Here we propose to measure the structure of three known drugs in water with a vision to understanding how this hydration effects their role in nature.