Polymer-stabilised lipid nanodiscs are discoidal structures composed on a central core of lipid bilayer encapsulated and stabilised in aqueous solution by amphipathic copolymers. Nanodiscs are emerging as powerful tools in the structural and functional characterisation of integral membrane proteins with potential application as a drug delivery platform. Recent studies have provided evidence of lipid exchange between nanodiscs in solution and lipid membranes at interfaces. We aim to complete our current study investigating the kinetics of lipid exchange by structurally characterising the interaction between nanodiscs and interfacial membranes by using specific deuteration and neutron reflectometry to uncover the mechanism behind this process. This will provide an understanding of the factors influencing lipid exchange enabling a more widespread use of nanodiscs in membrane research.