-
Interaction of an antimicrobial peptide from Lactobacillus gasseri supernatan...
A short peptide, composed of 12 amino acids (EFVFVAHAVPVM), presenting a strongly hydrophobic character, was recently isolated from Lactobacillus gasseri supernatant (AMP12).... -
Electrostatic Interactions between Floating Bilayers and Thiol Coated Interfa...
Bilayers which float below a self-assembled monolayer (SAM) coated solid support represent one of the most advanced membrane mimetics. Recently (RB 1720155) we assessed the... -
Assembling floating, very sparsely tethered, protein-lipid bilayers.
We have recently used Polref in to measure the assembly of tethered floating lipid bilayers. These are useful models of biological membranes in which a phospholipid bilayer is... -
Free Floating Higher Plant Membrane Mimetics
We have engaged in a long term effort to build accurate bio-mimetic systems for complex structural biology studies. Recently, we have found that thiolalkylamidealcohol... -
Interplay of apoptosis regulating Bcl-2 proteins at mitochondrial membranes u...
Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). This pathway is a major regulator in cell... -
Optimisation of Experimental Conditions for the Study of Anionic Self-Assembl...
We have developed a Self-assembled floating supported membrane sample system comprised of unsaturated phospholipid bilayers held ~1nm from a PEGylated charged alkane thiol SAM... -
Defects in the Core Oligosaccharide in Gram Negative Bacterial Outer Membrane...
The outer membrane of Gram negative bacterial is an effective barrier for many harmful agents. We have been developing and testing advanced models of the Gram negative bacterial... -
Assembling floating, very sparsely tethered, bilayers.
The cell membrane is a very important structure in biology and many laboratory based model systems have been developed to study it using biophysical techniques. Our particular... -
Lipid exchange between polymer stabilised nanodiscs and biomimetic bilayers a...
Polymer-stabilised lipid nanodiscs are discoidal structures composed on a central core of lipid bilayer encapsulated and stabilised in aqueous solution by amphipathic... -
A biophysical approach of studying the molecular interactions of a novel anti...
Gram negative (-ve) bacteria possess numerous defenses against antibiotics, not the least of them being the intrinsic permeability barrier afforded by their outer membrane (OM)... -
Mimicking Pathogens : Floating Gram Negative Bacterial Membranes Containing t...
Recently we have been able to show two advances in the creation of realistic models of the Gram negative bacterial outer surface for use in biophysical and structural studies.... -
Direct Observation of Gram Negative Bacterial Membrane Disruption by Supramol...
Cyclic peptides with alternating side chain stereochemistry are capable of self-assembling into long nanotubes. The conjugation of polymers to these peptides renders the... -
YMnO3-x : Mn(I) in a mixed metal oxide ?
Topotactic reduction of YMnO3 with CaH2 yields three new reduced phases. Two of these phases appear to have compositions close to YMnO2.5 but with very different anion vacancy... -
A study of the role of divalent cations in the stability of smooth LPS in out...
The Outer Membrane (OM) is found in bacteria which cause plague, cholera & Legionnaires disease. It is important as; a barrier to antibiotics & the site of... -
The Mechanism of Bam Mediated Outer Membrane Protein Folding
The proteins of the outer membrane of Gram-negative bacteria are critical for bacterial survival,from providing basic physiological functions, to impairing virulence and... -
Mimicking Pathogens : Floating Gram Negative Bacterial Membranes Containing t...
Recently we have been able to show two advances in the creation of realistic models of the Gram negative bacterial outer surface for use in biophysical and structural studies....
