Packing of DNA in glioma nuclei

DOI

To answer the question how DNA is packed inside the interphase nucleus at the micron scale, we propose SESANS experiment using contrast variation technique from human glioma nuclei. The previous SESANS measurements from chicken erythrocite and HeLa nuclei in D2O have shown exponential SESANS correlation function of the nucleus. The exponential decay of the SESANS function indicates that nucleas has a logarithmic correlation function on the micron scale [Iashina (2017)]. Logarithmic correlation function correspond to hierarchically branched structure like a tree. Such structure provides high accessibility of enzymes to specific gene site.

Identifier
DOI https://doi.org/10.5286/ISIS.E.RB1920181-1
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/105598484
Provenance
Creator Professor Sergey Grigoriev; Dr Robert Dalgliesh; Dr Wim Bouwman; Ms Ekaterina Iashina; Mr Chris Duif; Professor Sergey Grigoryev
Publisher ISIS Neutron and Muon Source
Publication Year 2022
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering
Temporal Coverage Begin 2019-09-30T07:30:00Z
Temporal Coverage End 2019-10-03T08:42:03Z