Here, we examined the impacts of low-pH priming on Manila clam broodstock and its impacts on broodstock physiology and larval outcomes. Measures of broodstock and larval phenotype were selected that would reveal how low pH impacts both generations and the transmission of environmental information between generations. In broodstock, we assessed energy metabolism and reproductive conditioning. Larval clams were reared in both ambient and low pH conditions to determine the impacts of priming on survival, growth, and shell formation. Based on different larval phenotypes resulting from the two broodstock pH conditions, we investigated the impact of maternal effects via egg lipidomes and maternal RNA. This dataset is included in the OA-ICC data compilation maintained in the framework of the IAEA Ocean Acidification International Coordination Centre (see https://oa-icc.ipsl.fr). Original data were downloaded from github (see Source) by the OA-ICC data curator. In order to allow full comparability with other ocean acidification data sets, the R package seacarb (Gattuso et al, 2024) was used to compute a complete and consistent set of carbonate system variables, as described by Nisumaa et al. (2010). In this dataset the original values were archived in addition with the recalculated parameters (see related PI). The date of carbonate chemistry calculation by seacarb is 2025-12-05.