-
Defects in the Core Oligosaccharide in Gram Negative Bacterial Outer Membrane...
The outer membrane of Gram negative bacterial is an effective barrier for many harmful agents. We have been developing and testing advanced models of the Gram negative bacterial... -
Interactions of de Novo Designed Antimicrobial Lipopeptides with Model Leafle...
In this work, we propose to exploit the unique capability of neutron reflection (NR) to study the structural changes of multi-component lipid monolayer models mimicking... -
Dynamic Adsorption of the Fusion Protein HSA-NEP at the Silica-Water Interface
HSA-NEP is a fusion protein with potential uses in treating Alzheimers disease. It consists of Neprilysin, a peptide degrading enzyme, linked to HSA, the most common protein in... -
Designing polymer therapeutics to diffuse through mucin
Progress in the development of nano-sized hybrid therapeutics and nano-sized drug delivery systems - "nanomedicines" - over the last decade has been remarkable. One key... -
Effect of oxidative stress on polyunsaturated lipid bilayers modulated by cho...
The exposure of biological membranes to reactive oxygen species is key for many pathological conditions, including inflammation, infection, or sepsis. Lipid peroxidation is... -
Neutron reflection study of effects of non-ionic alkyl ethoxylates on model w...
We propose to use NR to study the structural features of the model wheat wax films formulated from the known main components of long chain primary alcohols and an ester. By... -
Surface adsorption of short peptide surfactants
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly to lead to interfacial adsorption and solution nano-aggregation.... -
Validating calorimetric self aggregation models: Self aggregation of cationic...
Ligand self aggregation is a common problem when studying interactions with bio(macro)molecules. In particular for techniques requiring relatively high ligand concentrations,... -
Changes of phospholipid aggregate morphology induced by phospholipase hydrolysis
We propose to look at the interaction of the aggregates two phospholipids form with two phospholipase (PL) enzymes, PLA2 and PLC, which hydrolyse different ester groups in the... -
Interaction of keratin with surfactants studied by SANS
This proposal constitutes part of our ongoing study towards understanding how keratin, an important protein component of hair and skin, interacts with ionic surfactants using... -
Surface Layer Structures of Short Peptide Amphiphiles
Short peptide sequences consisting of hydrophobic and hydrophilic amino acid units are capable of self-assembly, leading to interfacial adsorption and solution nano-aggregation.... -
Using polymer / surfactant mixtures to optimise / enhance perfume delivery to...
This proposal is part of a funded (CASE) project, aimed at understanding the delivery of benefit actives (perfumes) to interfaces and the development of new self-assembled... -
pH-control of swelling and charge neutralization of thin hydrogel films
Hydrogels are widely used in biomaterials science, much due to excellent protein resistance, and physicochemical properties similar to biological tissue. Charge neutrality is... -
The effect of bilayer rigidity on the interactions with perfluoroalkyl compounds
Perfluoroalkyl substances (PFASs) are used extensively in industrial products although have been identified as emerging pollutants accumulating in wildlife and environment.... -
The Effect of Temperature on the Formation of Surfactant-Metal Ion Multilayer...
We have now established that multilayering at the air-water interface is a widespread phenomenon brought about by multivalent ions, whether polyelectrolyte, oligoelectrolyte or... -
The Interaction of Grp1 with Membranes Containing Signalling Phospholipids
This dataset has no description
-
Solubilisation of Drug Molecules in Nonionic Surfactant Micelles: Structural ...
This proposal aims to understand how the structure of non-ionic surfactant micelles affects the amount of fungicides solubilised. SANS is a technique unique for unravelling the... -
Interaction of keratin with surfactants studied by SANS
This proposal constitutes part of our ongoing study towards understanding how keratin, an important protein component of hair and skin, interacts with ionic surfactants using... -
Surface adsorption in multi-component biosurfactant-surfactant mixtures
This proposal is about the development of sustainable detergency based formulations, based on the blending of biosurfactants with conventional surfactants, and is part of a CASE... -
Interfacial adsorption of monoclonal antibody and antigen binding
Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element...