The exposure of biological membranes to reactive oxygen species is key for many pathological conditions, including inflammation, infection, or sepsis. Lipid peroxidation is known to deeply affect membrane properties such as structure or stability, but the specific roles of individual cell lipid components are complex and still not well understood. Here, we aim to study the structural consequences of lipid membrane oxidation induced by photoactivated TiO2 nanoparticles, of high pharmaceutical interest, and its dependence on lipid composition by using neutron reflectometry. Polyunsaturated lipid membrane models with different cholesterol contents and head group compositions will be used to investigate the role of these key membrane components in the oxidation process, and to elucidate any potential selectivity or modulation, crucial for the cellular response towards oxidative stress.