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Contrast-matching experiments to quantify pore connectivity in dolomites
Geologists are increasingly realizing the unique perspective that neutron scattering offersforunlocking the complex geologic histories of rocks. In this study, we propose to... -
Building a model for gastric mucins
Gastric mucus is a vital component for the protection of the stomach from the highly acidic gastric secretions, preventing autodigestion and providing mechanical protection.... -
SANS contrast measurements on important protein/DNA interactions from RCaH
This proposal is to perform SANS contrast measurements on three protein/DNA interactions currently worked on at the Research Complex at Harwell. This is part of an ongoing... -
Aggregation behaviour of aqueous hairy rod conjugated polyelectrolyte/surfact...
Small angle neutron scattering (SANS) will be used to characterise the structures of aggregates formed between the anionic conjugated polyelectrolyte... -
The solution structure of the OmpF¿Colicin N complex in neutral detergent by ...
Gram negative bacteria cause a wide range of diseases including meningitis, bubonic plague, gonorrhoea, diarrhoea, Legionnaires' disease and cholera. Their outer membrane... -
Solution structures of the immunologically important proteins IgG and C3b
IgG antibody represents one-third of new drugs currently in development. We will unravel the solution structures of the Fab and Fc fragments within IgG. Following our earlier... -
Lipopolysaccharide-antimicrobial peptide complexes in solution:elucidation of...
Lipopolysaccharide or endotoxin (LPS) is an amphiphilic macromolecule which constitutes the outer membrane of gram negative bacteria.During infection, LPS is released from the... -
Self-assembling behaviour of N-acyl amino acid-based surfactants
N-acyl amino acids are surfactants with attractive applications in different technological fields. They are referred to as mild surfactants because they are commonly considered... -
Developing a general approach to resolution of accessory proteins bound to cl...
Endocytosis plays a central role in allowing the selective transport of molecules, via membrane-derived vesicles, into cells. Vesicle formation is controlled by a complex... -
Structure-function studies of Replication Protein A, a crucial player in geno...
Replication protein A (RPA), the eukaryotic ssDNA binding protein, is a heterotrimeric protein required for almost all aspects of cellular DNA metabolism. RPA binds... -
Micelle formation from model surfactant binary and ternary compositions in th...
The effects of electrolytes on SLES3, C12E8 and LAS4 has been extensively studied, especially the effect on the critical micelle concentration of each surfactant. We wish to... -
Influence of polymer molecular weight on polymer stabilized lipid nanodiscs
Nanostructured lipid aggregates offer enormous potential as tools for membrane structural biology and biophysics. Poly(Styrene-Maleic Acid) stabilized lipid nanodiscs have a... -
DNA unwinding mechanism of the archaeal helicase PabMCM
The process of cell division requires precise duplication of the genetic material. The separation of the two strands of DNA and the progression of the replisome are driven by... -
Elucidating the unique role of non-standard collagen helices in forming key p...
The collagens are the most abundant proteins in mammalian systems, comprising up to 25% of human proteins. Their three-stranded triple helix structures are a major determinant... -
Solubilisation of Drug Molecules in Nonionic Surfactant Micelles: Structural ...
This proposal aims to understand how the structure of non-ionic surfactant micelles affects the amount of fungicides solubilised. SANS is a technique unique for unravelling the... -
Using SANS2D to resolve the opening of MscL clusters in proteoliposomes in re...
In bacteria, mechanosensitive ion channels such as MscL protect cells against osmotic shock. Although crucial for protecting cells, as with all ion channels, they have the... -
Lipid exchange dynamics between native lipoprotein particles and human cell m...
Atherosclerosis is the primary cause of death in westernized societies. Clinical indicators include not only the net lipoprotein concentration but also the ratio between the... -
OB Buffer - 40% D2O_SANS
This dataset has no description
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Determining the structure of the colicin OmpF complex
Large multiprotein complexes are the new frontier in structural biology. Individual proteins may be solved by X-ray crystallography but the relationships between subunits and... -
Solution Structure of the OmpF-TolA complex
Gram negative bacteria cause a wide range of diseases including meningitis, bubonic plague, gonorrhoea, diarrhoea, Legionnaires' disease and cholera. Their outer membrane...
