18 datasets found

As research on apoptosis has gained momentum, the importance of membrane lipids in this crucial cellular process is becoming clear.Previously, we have determined using NR and...

Polymer-based electronics have attracted huge interest due to their wide applicability to light emitting diodes, field effect transistors and photovoltaics. The aim of our...

In this proposal we investigate the adsorption of a key additive and functional group used in lubrication and wear applications using neutron reflection on a metal oxide...

Small molecule additives are used in melt processing, sometimes to lubricate extrusion or to provide bespoke hydrophilic surfaces. Both applications require the additive to...

We have recently been able to form a thin graphene oxide (GO) film with uniform thickness around 30±2Å from aqueous GO suspensions by spin coating (onto small wafers for...

Poly(amidoamine) (PAMAM) dendrimers have been identified as potential gene vectors. We have studied their association with surfactants, dilauroylphospholiponucleosides (DLPN),...

The objective of the present study is to reveal the temperature response of a cationic diblock copolymer, i.e. poly(N-isopropylacrylamide)...

The phase behaviour of aqueous surfactant systems and in particular the transition between a gel (Lb) and liquid crystalline (La) phase can be influenced by some low molecular...

Of concern to the bioprocessing industry is the manner in which polysorbates included in solution formulations of antibodies affect the kinetics and equilibrium state of...

Part One of the proposal is concerned with the fundamental structure of the TBM and aims to determine: (i) the impact of spacer molecule length on the dimensions of the bilayer...

A family of sterol-modified glycerophospholipids (SML) have been synthesized in which the sn-1 or sn-2 position is covalently attached to cholesterol and the alternative...

Beta-arrestins are proteins that regulate GPCR signaling, e.g. by recruiting endocytic components to remove the receptor from the plasma membrane. Our fluorescence microscopy...

Biological membrane in plane organisation is a challenging topic, specially since it has been suggested to depend on curvature. So far the main approach to study curvature...

Membrane Proteins (MPs) consist of about 1/3 of the proteome but the structural information available is very limited compared to that for soluble proteins. Despite this at...

Antibody-antigen binding has been extensively used in many technological applications such as immunoassays, chemical analysis and bionanotechnology. The crucial element...

We plan to investigate the interaction between amyloid proteins and model biomembranes deposited on solid surfaces. The model membranes will be single zwitterionic and mixed...

Following our very recent work on the dynamic co-adsorption of our control antibody COE-3 and nonionic surfactant PS80-7EO from the mixed solution, We request 3 days of Inter...

Human dihydroorotate dehydrogenase (DHODH) is an integral membrane protein found in mitochondria involved in the biosynthesis of pyrimidines. DHODH oxidizes dihydroorotate with...