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Copy of: Dynamics of amyloid protein fibril elongation using isotope-labelled...
This proposal combines small-angle neutron scattering with novel deuteration strategies to investigate amyloid protein fibrils. Variations in dynamics of elongation and breakage... -
Measuring phospholipid flip-flop rates across vesicle bilayers
Asymmetry across biological membranes is vital for a wide range of organelle and cellular functions. Significant differences in lipid composition have been found between the... -
Elucidating the unique role of non-standard collagen helices in forming key p...
The collagens are the most abundant proteins in mammalian systems, comprising up to 25% of human proteins. Their three-stranded triple helix structures are a major determinant... -
Interaction of keratin with surfactants studied by SANS
This proposal constitutes part of our ongoing study towards understanding how keratin, an important protein component of hair and skin, interacts with ionic surfactants using... -
Magnetic nanostructures of Fe-Ag and Fe-Au granular thin films
Nanogranular thin films of FexM100-x (M=Au,Ag; x=7,20,39) are an excellent system to study the magnetism of nanoparticles in diamagnetic matrices coupled by direct, RKKY and... -
Non-destructive investigation of pottery finds from Vörs-Máriaasszonysziget
The present application focuses on the determination of possible differences in pottery production methods during the Neolithic Period . Samples of coarse grain temper (organic... -
Using SANS to understand the structural basis for the rheology of molten choc...
Molten chocolate is a semi-solid suspension of (mostly) sugar, but also cocoa and milk solids in oil. In order to allow the sugar grains to flow past each other, either when the... -
Polymer conjugates for drug delivery
Complex polymer architectures such as comb polymers have been studied for their highly customisable chemical properties. Potential applications have been identified in a wide... -
Development of Creep Cavitation in Stainless Steel
Reheat cracking is a creep failure mode that has been observed in welded structures operating at high temperatures in the power generation industry. The failure results from the... -
Protein interactions at solid-liquid interfaces: The effect of affinity colum...
Biopharmaceuticals are manufactured using chromatographic procedures including adsorption and desorption processes at the solid-liquid interface. These events take place in... -
Micellization in H/F-Carbon surfactant mixtures used in fire-fighting foams
The aim is to probe the micellar compositions of fluorocarbon/ hydrocarbon mixtures used in commercial fire-fighting foam formulations (Figure 1) using contrast variation SANS.... -
Self-assembly in biosurfactants and biosurfactant / surfactant mixtures
This proposal is part of a new project which is a collaboration between Oxford, Newcastle, Ulster, and Unilever on the development of sustainable laundry detergents, using... -
Opening up microemulsion phases in CO2
New types of water-in-CO2 microemulsions using mixed surfactant systems will be investigated by high-pressure SANS (HP-SANS). Exciting new results (see report on RB820030) have... -
SANS studies of mixed phospholipid:sterol vesicles and their interaction with...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
SANS Studies of Nanostructures of Microfluidically Fabricated lipid Nanoparti...
We have developed a new approach for forming lipid nanoparticles (LNP) with and without interfering RNA and DNA from a microfluidic setup. The LNPs are formed by an ionisable... -
The formation of elongated aggregates in supercritical CO2 through the mixing...
This proposal involves manipulating the curvature of aggregated polar materials in supercritical CO2 (scCO2) by tuning the mixing ratio of fluorocarbon (FC) and hydrocarbon (HC)... -
Telechelic Polymer - Homopolymer Blends
We have recently embarked on a new 1 year project funded by Michelin to explore the self-associatation and mechanical properties of telechelic rubbery materials. Such materials... -
SANS study of the structure of surfactant stabilised Pt and Ru nanoparticles
Surfactants have been used to bind and disperse Pt and Ru nanoparticles during their synthesis. In this work, we propose to use SANS to determine the thickness and packing... -
Architecture of lipid-protein nanoglobules in velvet worm prey capture slime
Fiber fabrication in animals is an important inspiration source for polymeric materials. Velvet worm prey capture slime represents a unique way of fiber fabrication by using... -
Using SANS2D to resolve the opening of MscL clusters in proteoliposomes in re...
In bacteria, mechanosensitive ion channels such as MscL protect cells against osmotic shock. Although crucial for protecting cells, as with all ion channels, they have the...
