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Structural studies of protein at the oil-water interface
We would like to measure the adsorption isotherm for protein, milk B-casein using neutron reflectometery at the oil-water interface. These measurements will be carried out for... -
Magnetic interactions in ferromagnetic topological insulator multilayer struc...
Topological insulators are one of the most important recent discoveries in condensed matter physics. The topological surface state can become gapped when ferromagnetic order is... -
The mechanism of lipid transport in Gram-negative bacteria
The bacterial cell envelope is one of the best targets for antimicrobial development. It is this envelope that harbours the instruments of microbial warfare, preventing its... -
Do hydroxyl radicals penetrate the organic monolayer at the air-water interface?
The Earth¿s climate is strongly influenced by clouds. The oxidative processing of pollutants in clouds affects droplet size and optical properties, important climatic effects.... -
Interactions between lipoprotein particles from human serum and model blood v...
In westernised societies, atherosclerosis and its clinical consequences such as heart disease and stroke constitute the leading cause of death. Thus, the prevention or... -
Structure of a cationic polyelectrolyte adsorbed at an oppositely charged sur...
Adsorption of a charged polyelectrolyte onto an oppositely charged substrate is important for the understanding of many natural molecular events as well as for the development... -
Interaction of thermo-responsive deutrated nanogels with lipid monolayer at t...
Drug delivery through skin is an important delivery route. However, the outermost layer of the skin provides a formidable barrier to dermal absorption and penetration for... -
Magnetism in novel organic/inorganic hybrid spin-valve nanostructures.
We request 5 days (15 shifts) with CRISP to perform specular measurements on novel functionalized SrTiO3(substrate)/complex FM oxide/small molecules/ FM metal nanostructures to... -
Lipid monolayers at oil/water interfaces at high surface pressure as model bi...
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Determining the nanostructure of PCBM in thin film photovoltaics
Organic photovoltaics (OPVs) are a low cost alternative to existing photovoltaic materials. The efficiency of OPVs is steadily increasing towards the point where their cost per... -
Protein Adsorption at the PDMS Oil/Water Interface
Neutron reflection has been successfully used to measure the conformation of proteins adsorbed at the oil/water interface. However, in several such experiments, hexadecane has... -
Self-assembled Floating Lipid Bilayers: What Forces Are Causing the Bilayer t...
Recently (RB19100102) we have discovered that floating bilayers composed of fluid phase lipids can be produced by deposited vesicles onto charge modified oligo(ethylene... -
Magnetic proximity effect and in-plane correlations in amorphous CoAlZr/FeZr ...
The purpose of this project work is to establish a broader understanding of the magnetic proximity effect observed in a magnetic amorphous multilayer. This will be achieved by... -
Neutron scattering to characterise protein interactions with solid-liquid int...
Objectives of this proposal aim to shed light on how adsorption processes such as protein A chromatography, used to purify biologics, affect protein propensity for aggregation.... -
Does spinodal dewetting proceed by peristalsis?
We shall demonstrate the use of neutron reflectometry to obtain three-dimensional structures in a non-invasive experiment. Spinodal dewetting is one of the few areas where... -
Introducing the O-antigen into Bacterial Outer Membrane Models
The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the... -
The membrane lipid composition regulates the orientation of Tissue Factor ext...
Tissue Factor (TF) is a membrane protein located on the cell surfaces of extravascular cells. TF activity is fundamental for normal homeostasis- the physiological process which... -
Elucidating molecular mechanism of membrane disruption by designed α-hel...
We have previously shown that peptides such as G(IIKK)4I-NH2 (G4) can kill bacteria and inhibit cancer cell growth whilst remaining benign to mammalian host cells. We have also... -
Di-chain sulfobetaine monolayers at the air-solution interface
Here we wish to continue our investigation of sulfobetaine surfactants in which the charges on the zwitterionic headgroup are reversed compared to those on zwitterionic... -
Conformational changes on interaction of cytochrome c with lipid monolayers.
The main objective of the present work is to gain an understanding of the interaction of the cationic protein, cyt c with anionic lipid membranes. This objective will be...
