152 datasets found

An increasing number of potential drug molecules are extremely water insoluble, limiting their commercialisation as medicines. Solubilisation of drug in surfactant micelles is a...

We are developing a new protocol for the preparation of lipid bilayers suitable to host membrane proteins with control on their orientation. Our proposed strategy is based on...

Antimicrobial peptides (AMPs), also called host defense peptides, are part of the innate immune system of essentially all species, from bacteria themselves to mammals to protect...

Purothionins and defensins are basic, amphiphilic, cysteine-rich and low molecular weight plant defence proteins. These proteins are active against a broad range of...

We propose to explore the morphology of binary mixtures of poly(ethylene oxide), a biomimetic macromolecule, and two different ionic liquids, differing in their hydrogen bonding...

Conventional ways to administer and deliver drugs have reached its limitations. These methods can be still used for small and simple molecules. However, new carriers have to be...

Cellulose is produced over tens of billions of tons every year in the world. It is one of the most abundant natural polymer resources. Compared with petroleum-based polymers,...

Chitosan is a linear polysaccharide that is biocompatible and biodegradable. Chitosan has a number of unique chemical and biological features including its cationic nature and...

Two days of beamtime on GEM will be used to analyse the structure of the fast lithium-ion conductive phases formed by anion doping the hydrogen storage material LiBH4 with...

Solvents are integral part of the world and so many charge transfer processes take place in a solutions. Unfortunately, not much is known about the microstructure of solvents...

Protein-surfactant interactions at an interface play an important role for broad applications in the chemical, dairy, cosmetic and pharmaceutical industries. Rubisco is the most...

Bacterial membranes contain safety valves called mechanosensitive ion channels, which protect the bacterium from changes in the osmotic pressure of their environment. However,...

The non-covalent interactions between aromatic rings are of fundamental importance in large number biological and chemical processes. The local structure of aromatic liquids is...

The aim of this study is to try to understand how antimicrobial peptides bind to model lipid monolayers mimicking different cell membrane types. Following our previous work,...

Bacteria growing resistant to common antibiotics is a growing problem and research in new types of medicines which do not induce resistance is therefore very important. Novel...

The yeast Candida glabrata is becoming an increasing cause of infections. We have developed RNA interference tools that allow us to study the virulence and resistance mechanisms...

The recent discovery of skyrmions and skyrmion lattices in materials with no inversion symmetry and their corresponding potential applications of Skyrmions in magnetic...

Human dihydroorotate dehydrogenase (DHODH) is an integral membrane protein found in mitochondria involved in the biosynthesis of pyrimidines. DHODH oxidizes dihydroorotate with...

Polymers are commonly used in drug delivery to create dosage forms that enable delivery of the active ingredient to the site of action within the body. Towards controlled drug...

Physical developer (PD) is a latent fingerprint development technique that is highly effective on paper and related surfaces, notably banknotes. The process exploits a redox...