103 datasets found

Influenza virus is a pathogen of great medical importance that causes seasonal epidemics and sporadic pandemics. Among the least understood events of the influenza virus...

Complement comprises key proteins in innate immunity that forms a major defence and clearance system in blood. CFH is the major regulator of active C3b formed from C3. C3d is a...

Summary. Silicatein in marine sponges catalyses the condensation of silica but the mechanism of layer-by-layer growth of the silica spicule is unknown since sufficient...

Liposomes are lipid-based, water-filled vesicles with wide-ranging applications in diagnostics and drug delivery. Phospholipases (PLs) are enzymes that cleave specific bonds in...

We have previously used LOQ to identify the complex (polyplex) structures formed between a short single strand DNA and a cationic diblock copolymer MPC30-DEA60. The SANS...

Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Polymer stabilized lipid bilayer discs...

Cytochromes P450 play a key role in drug metabolism in man. Electrons are supplied to the cytochromes by NADPH through the flavoprotein NADPH-cytochrome P450 reductase (CPR)....

The proteins of the outer membrane of Gram-negative bacteria are critical for bacterial survival, from providing basic physiological functions, to impairing virulence and...

Conjugation of therapeutic proteins to polymers is well established but most methods result in multi-site and multiple conjugation, crosslinking resulting in lack of orientation...

Human dihydroorotate dehydrogenase (DHODH) is an integral membrane protein found in mitochondria involved in the biosynthesis of pyrimidines. DHODH oxidizes dihydroorotate with...

The proteins of the outer membrane of Gram-negative bacteria are critical for bacterial survival, from providing basic physiological functions, to impairing virulence and...

Polymer stabilized lipid nanodiscs offer enormous potential as tools for enabling membrane protein structural studies & biophysics. Polymer stabilized lipid bilayer discs...

Following our previous study of adsorption of globular lysozyme and BSA at the oil/water interface by neutron reflection, we continue to explore how unfolding of globular...

This proposal is Disordered Materials Express. In collaboration IPCF-CNR, Bari,Italy, we synthesized particular coreshell (inorganic/organic materials) nanomaterials (NPs)....

It is difficult for the naked external gene to become internalized due to its similar charge to the extracellular membrane surface. Various cationic copolymers and cationic...

Assembly of the peptidoglycan later of bacterial cell walls is a validated target for anti-bacterial agents: the late transpeptidation and transglycosylation steps are inhibited...

Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a...

The proteins of the outer membrane of Gram-negative bacteria are critical for bacterial survival, from providing basic physiological functions, to impairing virulence and...

The microscopic dynamics of associative polymers that self-assemble into micellar structures play a key role for their macroscopical properties, with important implications for...

The proteins of the outer membrane of Gram-negative bacteria are critical for bacterial survival. The understanding of how these proteins are targeted and folded into this...