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Encapsulation of Non-Steroidal Anti-Inflammatory Drugs Using Novel Pluronic G...
The research topic is encapsulation of a hydrophobic drug, flurbiprofen, using novel amphiphilic graft copolymers (AGCs). The AGCs of interest are shown in Figure 1: Preliminary... -
Structure and interactions in model and real anti-reflective coatings
This proposal seeks to exploit contrast variation SANS to study a multi-component system, spanning a wide range of colloidal length scales. The multi-component system under... -
Co-assembly of gold nanoparticles with wormlike micelles
Gold nanoparticles (GNPs) are attracting tremendous interest in nanotechnology due to their plasmonic properties, in particular the localized surface plasmon resonance effect... -
Surfactant aggregation in magnetic ionic liquids
This proposal aims to explore aggregation behavior of common surfactants in magnetic ionic liquids (MILs) and to investigate the effect of a magnetic field on aggregate size,... -
Biomolecular Cryoprotection in Deep Eutectic Solvents
Protecting biomolecules, such as proteins and enzymes, from the effects of cooling and freezing is important for the storage and handling of pharmaceuticals. Deep eutectic... -
SANS studies of mixed phospholipid:sterol vesicles and their interaction with...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
Using SANS2D to resolve the opening of MscL clusters in proteoliposomes in re...
In bacteria, mechanosensitive ion channels such as MscL protect cells against osmotic shock. Although crucial for protecting cells, as with all ion channels, they have the... -
Interactions of Cationic Surfactants with Phospholipid Vesicles: Influence of...
Surfactants are frequently used in personal care products to improve the wetting and oil solubilizing qualities of the products, which also leads to the skin irritation by... -
Controlling the morphology of fullerene-free polymer solar cells using additi...
We have recently demonstrated, using small angle neutron scattering in combination with other techniques, that in organic photovoltaic devices (OPVs) the additive... -
Dynamics of amyloid protein fibril growth using isotope-labelled SANS
This proposal aims use a novel approach whereby deuterated amyloid peptide fibrils are givenhydrogenated growing ends, and analysed using SANS. The data will enable us to... -
SANS study of hollow nanoparticles and their solvent release
Hollow nanoparticles (HNP) have been successfully used for encapsulation and controlled release of biochemicals such as drugs, DNA, and dyes. However no in-situ method has been... -
Structure of alkylated aza-crown ether inverse micelles
Ion transfer through fluid-fluid interfaces plays decisive roles in many natural and industrial processes. In studies of Cu(II) transport by Permeation Liquid Membrane (PLM)... -
Surfactant induced gelation of TEMPO-oxidized cellulose; Using betaine-based ...
Our group has been working cellulose nanofibrils (OCNF) which form hydrogels in the presence of certain additives. Previously, we have studied the effect of salt, single... -
Effect of surfactant head group on micelle structure of drug containing micelles
The aim of the current project is to probe (at the nanometer length scale) the relationship between the solution structures of a surfactant molecule, the aggregate(s) it forms... -
Effect of pH on the shape of oil-in-water microemulsions formed by a zwitteri...
Despite interest in microemulsions as drug delivery vehicles, there is a lack of structural understanding to justify the formulations used. The present study examines the use of... -
Small-Angle Neutron Scattering studies of a bacterial colonization factor
We plan to carry out SANS experiments on a bacterial colonization factor to elucidate how it interacts with chitin, which is found on the surface of plankton and crustaceans.... -
Small angle neutron scattering study on the interaction between antimicrobial...
Bacterial endotoxins, or lipopolysaccharide (LPS), released from the gram negative bacterial membrane, form different aggregates in solution which morphology depends on the type... -
The solution structure of E.coli peripheral membrane protein FtsA solubilised...
We will measure the solution structure of a protein complex from bacteria essential for cell division. The two proteins, FtsA and FtsZ, are known to interact with each other... -
SANS studies of phospholipid:sterol vesicles and the membrane interactions of...
The increasing incidence of pathogenic fungi resistant to treatment with amphotericin B (AmB) has created a demand for novel anti-fungal agents that can circumvent the... -
Structure of Cellulose Nanofibril Gels
This proposal is part of a new project based on understanding the formation of gels in suspensions of partially oxidised cellulose nanofibrils with small amounts of salt or...
