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Interaction of the intrinsically-disordered linker histone C-terminal tail wi...
In cells, the genome needs to be tightly packaged in the nucleus as "chromatin" while still allowing access to the cellular machinery responsible for gene expression. The first... -
Using negative muons as a non-destructive probe of biomaterials
Expanding the provision of tools for trace element analysis of biomaterials is very attractive, especially where the tools can be used non-destructively and permit analysis... -
Membrane-stacking Properties of Mutant Myelin Proteins
Myelin is the multilamellar structure that ensheaths axons and accelerates nervous impulses in the nervous system. The fine structure of myelin remains to be further... -
Structural Resolution of Colloidal Iron Nanoparticles used in Clinical Applic...
We propose to use the NIMROD diffraction instrument to produce high-resolution data on the structure of various nanoparticulate iron oxide-hydroxides. Although widely used in a... -
The potential for leaf pruning to improve water use efficiency of maize under...
Climate change will likely increase the frequency of extreme events, such as drought, and there is a need to increase the resilience of food crops, particularly in arid regions.... -
Structural Observation of the Self-Assembly Kinetics of Cyclic Peptide Nanotubes
Cyclic peptides with alternating side chain stereochemistry are capable of self-assembling into long nanotubes. The conjugation of polymers to these peptides renders the... -
A Study of Creep Induced Cavitation in Porcelain Dental Veneer using Small An...
Current manufacturing techniques used in the production of yttria-stabilized zirconia/porcelain dental prostheses lead to high rates of brittle failure from stress... -
Membrane Proteins Gramicidin & ZipA in Polymer-Stabilized Lipid Nanodiscs
Poly(Styrene-Maleic Acid) stabilized lipid nanodiscs offer enormous potential as tools for membrane structural biology and biophysics. Polymer stabilized nanodiscs have a number... -
Does Deuteration Change More then the Phonon Spectrum?
Our recent express measurments on protonated and deuterated 7,7,8,8-tetracyanoquinodimethane (TCNQ) have highlighted some interesting differences between the two. We seek to... -
Antibiotic Interactions with models of the Gram negative bacterial outer memb...
This dataset has no description
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Lysozyme Functionalised Titania: A Kinetic & Structural Optimisation
Hospital-acquired infections of medical devices result in approximately 100,000 deaths each year in the US alone, it is therefore a priority to tackle this. To this end, we have... -
Introducing the O-antigen in Bacterial Outer Membrane in vitro Models Pt. II ...
The Gram negative bacterial outer membrane protects the bacterium from external toxins such as antibiotics. This is partially responsible for Gram negative bacteria becoming the... -
Nanoarchitecture of folded maltose binding protein hydrogels
Proteins are the workhorses of the cell, performing a huge array of functions from providing mechanical strength to molecular recognition & binding. They perform these... -
The origins of Biosurfactant self assembly
Biosurfactants are becoming more commonplace in pharmaceuticals, vaccines and other forms of medicines. With the biobased economy growing substantially and pressure to reduce... -
Structural evolution of self-assembled cyclic-peptide hydrogels
Cyclic peptides which can self-assemble into long nanotubes provide unique properties which can be tailored for a diverse range of biomedical applications. Recently, we have... -
Elucidating the interaction mechanism of novel antimicrobial dendrimer on rec...
Antimicrobial drug resistance is an increasing problem worldwide. The prospect of exploiting dendritic structures as scaffolds for antimicrobial peptide (AMP) based agents with... -
Does Deuteration Change More then the Phonon Spectrum?
Our recent express measurments on protonated and deuterated 7,7,8,8-tetracyanoquinodimethane (TCNQ) have highlighted some interesting differences between the two. We seek to... -
Microscopic interactions between water and urea and a beta-turn forming peptide
The mechanisms by which proteins fold and unfold in aqueous solutions is still not well understood. Depsite urea being a common protein denaturant, there is no atomic level... -
Investigation of Folded Globular Maltose Binding Protein Based Hydrogels
We have developed a new model to describe the structural architecture of hydrogels composed of cross-linked maltose binding proteins (MBP), supported by multiple techniques... -
Purothionin binding to model fungal lipid membranes
Thionins are basic, amphiphilic, cysteine-rich and low molecular weight plant defence proteins. These proteins are active against a broad range of phytopathogenic fungi, and can...
