Structural Resolution of Colloidal Iron Nanoparticles used in Clinical Applications

DOI

We propose to use the NIMROD diffraction instrument to produce high-resolution data on the structure of various nanoparticulate iron oxide-hydroxides. Although widely used in a range of applications ¿ including imaging of cancers and the clinical correction of iron deficiency anaemia (IDA) ¿ structural insights into these materials are lacking. Specifically, characterisation of mineral phase and core-coating interactions are required ¿ both from a fundamental and an applied science perspective. We intend to establish the parent mineral phases of relevant materials and examine the impact of surface coatings upon their lattice structures via comparison to phase-pure samples of ferrihydrite and akaganéite. Hydrogen-deuterium substitutions will be employed to enhance structural contrast.

Identifier
DOI https://doi.org/10.5286/ISIS.E.49912824
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/49912824
Provenance
Creator Dr Daniel Bowron; Dr Helen Chappell; Mr Will Thom; Dr Jonathan Powell; Dr Nuno Faria
Publisher ISIS Neutron and Muon Source
Publication Year 2017
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Medicine; Natural Sciences
Temporal Coverage Begin 2014-05-12T23:00:00Z
Temporal Coverage End 2014-05-15T23:00:00Z