Lysozyme Functionalised Titania: A Kinetic & Structural Optimisation

DOI

Hospital-acquired infections of medical devices result in approximately 100,000 deaths each year in the US alone, it is therefore a priority to tackle this. To this end, we have developed an method of functionalising titania surfaces with lysozyme, an enzyme which breaks down the cell walls of bacteria. This approach shows great promise for killing bacteria when compared to native titania surfaces, but any further improvement requires an in-depth understanding of the structure of the surfaces. In particular, it's known that the mechanism of lysozyme adsorption to the surfaces plays an important role. Therefore, within the scope of this study we propose to use reflectometry to understand the structural parameters of each step in the functionalisation process, followed by an in-depth kinetic study of the adsorption process to complement ongoing gravimetric studies.

Identifier
DOI https://doi.org/10.5286/ISIS.E.86777912
Metadata Access https://icatisis.esc.rl.ac.uk/oaipmh/request?verb=GetRecord&metadataPrefix=oai_datacite&identifier=oai:icatisis.esc.rl.ac.uk:inv/86777912
Provenance
Creator Dr Rebecca Welbourn; Dr Rob Barker; Dr Gavin Hazell
Publisher ISIS Neutron and Muon Source
Publication Year 2020
Rights CC-BY Attribution 4.0 International; https://creativecommons.org/licenses/by/4.0/
OpenAccess true
Contact isisdata(at)stfc.ac.uk
Representation
Resource Type Dataset
Discipline Biology; Biomaterials; Chemistry; Engineering Sciences; Life Sciences; Materials Science; Materials Science and Engineering; Medicine; Natural Sciences
Temporal Coverage Begin 2017-10-02T08:00:00Z
Temporal Coverage End 2017-10-06T08:00:00Z