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Lipopolysaccharide Functions as Bacterial Receptors to Antimicrobial Peptides
Neutron reflection (NR) is well established for studying molecular films such as lipid monolayers. Its high depth resolution combined with deuterium labelling can determine the... -
Determination of kinetics of adsorption and layer thickness of lamellar gel s...
The phase behaviour of aqueous surfactant systems and in particular the transition between a gel (Lb) and liquid crystalline (La) phase can be influenced by some low molecular... -
Phospholipid exchange between tethered bilayers and vesicles
Our objective is to create asymmetric solid surface tethered bilayers (tBLMs) with the the outer leaflet predominately populated by charged phospholipids. tBLMs are produced by... -
The Interactions of Blood Components with Models of the Gram Negative Bacteri...
One of the major challenges in the fight against antimicrobial resistance is the development of antimicrobial compounds that selectively disrupt bacterial membranes and leave... -
Investigation of PVC plasticizers on phospholipid monolayers
Plastic bags are used as containers for storage of donated blood. These bags are typically made out of PVC plasticized with dialkylphthalates (e.g. DEHP), which migrates into... -
INTERACTIONS OF PAMAM DENDRIMERS WITH DESIGNER BIOSURFACTANTS AT THE SOLID/LI...
Poly(amidoamine) (PAMAM) dendrimers have been identified as potential gene vectors. We have studied their association with surfactants, dilauroylphospholiponucleosides (DLPN),... -
Model anionic/non ionic surfactant adsoption at the interface below room temp...
An experiment performed on INTER last year found extreme non ideal mixing between C12E8/SLES3 at the air water interface: this feature became more extreme as the temperature... -
Floating Bilayer Mimics of the Gram Negative Bacterial Outer Membrane
The gram-negative bacterial membrane is of extreme medical importance. The two main lipid components of the outer membrane are lipopolysaccharides (LPS's) and DOPE. We will... -
Self-assembling antimicrobial peptides: interactions with model lipid membranes
We propose to investigate antimicrobial peptides that self-assemble into well-defined nanostructures. Previous SAXS results have shown that the peptides form rather robust... -
Effect of high temperatures on the adsorption of benzotriazole onto copper/co...
Benzotriazole (BTAH) is a very effective corrosion inhibitor for copper and its alloys in both water and in oils. BTAH is introduced as a corrosion inhibitor in oil based... -
The impact of polyelectrolytes on surfactant adsorption onto cellulose surfaces
Studying surfactant and mixed surfactant adsorption on model solid surfaces, which mimic real surfaces such as fabrics, hair and skin, is starting to provide a real insight into... -
Characterising the membrane binding interaction of plant annexin Gh1
Annexins are a ubiquitous group of membrane associated proteins found in animals, plants and fungi. They are linked to wide range of functions including phospholipid... -
Neutron reflectivity of water soluble conjugated polymer/surfactant films
Water-soluble conjugated polymers (WSCP) are an important class of materials which have received great attention as active materials in optoelectronic devices and in biosensing.... -
Understanding the antimicrobial activity of the salivary protein Histatin 5
The goal of this project is to understand the antimicrobial activity of the intrinsically disordered salivary protein Histatin 5, which acts in defence against oral candidiasis... -
Adsorption of Sodium Bis-(2-ethylhexyl)phosphate on a-Alumina
In this proposal we investigate the adsorption of a key additive and functional group used in lubrication and wear applications using neutron reflection on a metal oxide... -
Magnetic contrast NR to resolve MscL opening under PXG challenge
In bacteria, mechanosensitive ion channels such as MscL protect cells against osmotic shock, but, as with all ion channels, they have the potential to act as an Achilles heel,... -
Lipid exchange between high density lipoprotein (HDL) and model phosphatidylc...
Lipoproteins are the main carriers of lipids in the body. HDL is believed to favor cholesterol removal and decrease the risk to develop atherosclerosis and related... -
Interactions of polyfluorinated substances with a phospholipid bilayer
Poly- and perfluoroalkyl substances (PFASs) have been used in various industrial applications and consumer products, but have received increasing global concern due to their... -
Adsorption of perfluoroalkyl substances to solid soil interface to elucidate ...
Perfluoroalkyl substances (PFASs) are stable compounds and commercially desirable. They are widely used, for example, as surfactants in textile and paper products and in aqueous...